{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(23)"],"submitter":["Argueta C"],"pubmed_abstract":["Consisting of more than 11,000 members distributed over five families, the tautomerase superfamily (TSF) is a large collection of proteins with diverse biological functions. While much attention has been given to individual TSF enzymes, a majority remain structurally and functionally uncharacterized. Given its large size, studying a representative member of each family offers a viable approach for extracting mechanistic insights applicable to the entire superfamily. In this study, cis-3-chloroacrylic acid dehalogenase (cis-CaaD), 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI), malonate semialdehyde decarboxylase (MSAD), and 4-oxalocrotonate tautomerase (4-OT) were referenced against the well-studied macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT) using "],"journal":["International journal of molecular sciences"],"pagination":["12617"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11641302"],"repository":["biostudies-literature"],"pubmed_title":["Conformational Flexibility of the C-Terminal Region Influences Distal Active Site Residues Across the Tautomerase Superfamily."],"pmcid":["PMC11641302"],"pubmed_authors":["Argueta C","Pantouris G","Parkins A"],"additional_accession":[]},"is_claimable":false,"name":"Conformational Flexibility of the C-Terminal Region Influences Distal Active Site Residues Across the Tautomerase Superfamily.","description":"Consisting of more than 11,000 members distributed over five families, the tautomerase superfamily (TSF) is a large collection of proteins with diverse biological functions. While much attention has been given to individual TSF enzymes, a majority remain structurally and functionally uncharacterized. Given its large size, studying a representative member of each family offers a viable approach for extracting mechanistic insights applicable to the entire superfamily. In this study, cis-3-chloroacrylic acid dehalogenase (cis-CaaD), 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI), malonate semialdehyde decarboxylase (MSAD), and 4-oxalocrotonate tautomerase (4-OT) were referenced against the well-studied macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT) using ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-04-22T03:22:02.998Z","creation":"2025-04-03T23:26:32.517Z"},"accession":"S-EPMC11641302","cross_references":{"pubmed":["39684328"],"doi":["10.3390/ijms252312617"]}}