{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zweck E"],"funding":["Novo Nordisk Fonden"],"pagination":["1990-2003"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11643129"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["150(25)"],"pubmed_abstract":["Background
In DanGer Shock (the Danish-German Cardiogenic Shock trial), use of a microaxial flow pump (mAFP) in patients with ST-segment-elevation myocardial infarction-related cardiogenic shock led to lower all-cause mortality but higher rates of renal replacement therapy (RRT). In this prespecified analysis, rates and predictors of acute kidney injury (AKI) and RRT were assessed.Methods
In this international, randomized, open-label, multicenter trial, 355 adult patients with ST-segment-elevation myocardial infarction-related cardiogenic shock were randomized to mAFP (n=179) or standard care alone (n=176). AKI was defined according to RIFLE criteria (Risk, Injury, Failure, Loss, and End-stage kidney disease) and assessed using logistic regression models. Use of RRT was ass"],"journal":["Circulation"],"pubmed_title":["Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial."],"pmcid":["PMC11643129"],"funding_grant_id":["NNF23OC0082430"],"pubmed_authors":["Hommel J","Schulze C","DanGer Shock Investigators","Ravn HB","Zimmer S","Christensen S","Zweck E","Schmidt H","Westenfeld R","Christiansen EH","Eiskjær H","Fryldand M","Nordbeck P","Kelm M","Polzin A","Terkelsen CJ","Boesgaard S","Moebius-Winkler S","Wachtell K","Kjaergaard J","Sorensen R","Engstrom T","Clemmensen P","Werner N","Hassager C","Beske RP","Mangner N","Linke A","Udesen NLJ","Moller JE","Panoulas V","Junker A","Veien KT","Lassen JF","Jensen LO","Schulze PC","Schafer A","Westermann D","Skurk C","Holmvang L","Lonborg J","Woitek FJ","De Haas I"],"additional_accession":[]},"is_claimable":false,"name":"Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial.","description":"Background
In DanGer Shock (the Danish-German Cardiogenic Shock trial), use of a microaxial flow pump (mAFP) in patients with ST-segment-elevation myocardial infarction-related cardiogenic shock led to lower all-cause mortality but higher rates of renal replacement therapy (RRT). In this prespecified analysis, rates and predictors of acute kidney injury (AKI) and RRT were assessed.Methods
In this international, randomized, open-label, multicenter trial, 355 adult patients with ST-segment-elevation myocardial infarction-related cardiogenic shock were randomized to mAFP (n=179) or standard care alone (n=176). AKI was defined according to RIFLE criteria (Risk, Injury, Failure, Loss, and End-stage kidney disease) and assessed using logistic regression models. Use of RRT was ass","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-02T10:45:56.316Z","creation":"2025-04-04T02:54:46.71Z"},"accession":"S-EPMC11643129","cross_references":{"pubmed":["39462276"],"doi":["10.1161/CIRCULATIONAHA.124.072370"]}}