biostudies-literatureZweck ENovo Nordisk Fonden1990-2003https://www.ebi.ac.uk/biostudies/studies/S-EPMC11643129biostudies-literatureUnknown150(25)<h4>Background</h4>In DanGer Shock (the Danish-German Cardiogenic Shock trial), use of a microaxial flow pump (mAFP) in patients with ST-segment-elevation myocardial infarction-related cardiogenic shock led to lower all-cause mortality but higher rates of renal replacement therapy (RRT). In this prespecified analysis, rates and predictors of acute kidney injury (AKI) and RRT were assessed.<h4>Methods</h4>In this international, randomized, open-label, multicenter trial, 355 adult patients with ST-segment-elevation myocardial infarction-related cardiogenic shock were randomized to mAFP (n=179) or standard care alone (n=176). AKI was defined according to RIFLE criteria (Risk, Injury, Failure, Loss, and End-stage kidney disease) and assessed using logistic regression models. Use of RRT was assCirculationMicroaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial.PMC11643129NNF23OC0082430Hommel JSchulze CDanGer Shock InvestigatorsRavn HBZimmer SChristensen SZweck ESchmidt HWestenfeld RChristiansen EHEiskjær HFryldand MNordbeck PKelm MPolzin ATerkelsen CJBoesgaard SMoebius-Winkler SWachtell KKjaergaard JSorensen REngstrom TClemmensen PWerner NHassager CBeske RPMangner NLinke AUdesen NLJMoller JEPanoulas VJunker AVeien KTLassen JFJensen LOSchulze PCSchafer AWestermann DSkurk CHolmvang LLonborg JWoitek FJDe Haas IfalseMicroaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial.<h4>Background</h4>In DanGer Shock (the Danish-German Cardiogenic Shock trial), use of a microaxial flow pump (mAFP) in patients with ST-segment-elevation myocardial infarction-related cardiogenic shock led to lower all-cause mortality but higher rates of renal replacement therapy (RRT). In this prespecified analysis, rates and predictors of acute kidney injury (AKI) and RRT were assessed.<h4>Methods</h4>In this international, randomized, open-label, multicenter trial, 355 adult patients with ST-segment-elevation myocardial infarction-related cardiogenic shock were randomized to mAFP (n=179) or standard care alone (n=176). AKI was defined according to RIFLE criteria (Risk, Injury, Failure, Loss, and End-stage kidney disease) and assessed using logistic regression models. Use of RRT was ass2024-01-01T00:00:00Z2024 Dec2026-06-02T10:45:56.316Z2025-04-04T02:54:46.71ZS-EPMC116431293946227610.1161/CIRCULATIONAHA.124.072370