biostudies-literatureUnknownWalters MKNICHD NIH HHSNIAID NIH HHSWellcome Trust<h4>Background</h4>Eliminating HIV vertical transmission (VT) is a global priority and monitored by estimating paediatric HIV infections with the Joint United Nations Programme on HIV/AIDS supported Spectrum AIDS Impact Module (Spectrum-AIM). Recent innovations in antiretroviral therapy (ART) service delivery models and first-line regimens aimed to reduce VT probabilities. We conducted a systematic review and meta-analysis to estimate VT probabilities by maternal immunologic and treatment status.<h4>Methods</h4>We combined an updated systematic review with previous data in meta-regression models to estimate VT probabilities and determinants. We searched multiple databases for peer-reviewed English-language studies from all regions published between January 2018 and February 2024 with VT damedRxiv : the preprint server for health sciences2024.12.03.24318418https://www.ebi.ac.uk/biostudies/studies/S-EPMC11643157biostudies-literatureProbability of vertical HIV transmission: A systematic review and meta-regression.PMC11643157T32 AI007140R01 AI152721F31 HD116617Walters MKSabin MImai-Eaton JWHicks SGlaubius RStover JRichey AKyu HPowis KBarry MBoily MCBulterys MALouden DMahy MMofenson LfalseProbability of vertical HIV transmission: A systematic review and meta-regression.<h4>Background</h4>Eliminating HIV vertical transmission (VT) is a global priority and monitored by estimating paediatric HIV infections with the Joint United Nations Programme on HIV/AIDS supported Spectrum AIDS Impact Module (Spectrum-AIM). Recent innovations in antiretroviral therapy (ART) service delivery models and first-line regimens aimed to reduce VT probabilities. We conducted a systematic review and meta-analysis to estimate VT probabilities by maternal immunologic and treatment status.<h4>Methods</h4>We combined an updated systematic review with previous data in meta-regression models to estimate VT probabilities and determinants. We searched multiple databases for peer-reviewed English-language studies from all regions published between January 2018 and February 2024 with VT da2025-01-01T00:00:00Z2025 Apr2025-08-14T03:05:36.679Z2025-08-14T03:05:36.679ZS-EPMC116431573967742210.1101/2024.12.03.24318418