{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Leung YY"],"funding":["European Research Council","Dutch Research Council (NWO)","Wellcome Trust"],"pubmed_abstract":["The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.2 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, det"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.12.03.24317000"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11643159"],"repository":["biostudies-literature"],"pubmed_title":["Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset."],"pmcid":["PMC11643159"],"funding_grant_id":["340755","175.010.200","047.017.043"],"pubmed_authors":["Wheeler NR","Mena PR","White H","Ren Y","Bass L","Katanic Z","Naj AC","Wang H","Schellenberg GD","Zhao Y","Cheng PL","Cuccaro M","Haines JL","Pericak-Vance MA","Valladares O","Nicaretta H","Martin E","Qu L","Farrer LA","Kuksa PP","Carter L","Jin J","Vardarajan BN","Mayeux RP","Lee WP","Kirsch M","Wang LS","Saravanan N","Greenfest-Allen E","Hohman TJ","Zhu C","Alzheimer’s Disease Sequencing Project","Kunkle BW","Kuzma AB","Dalgard C","Turner SL","Bush WS","Cantwell L","Iqbal T","Gunasekaran TI","Toga A","Zhang X","Leung YY","Farrell JJ","Gangadharan P"],"additional_accession":[]},"is_claimable":false,"name":"Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset.","description":"The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.2 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, det","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-27T00:27:31.269Z","creation":"2025-04-06T17:50:42.725Z"},"accession":"S-EPMC11643159","cross_references":{"pubmed":["39677464"],"doi":["10.1101/2024.12.03.24317000"]}}