biostudies-literatureUnknownLeung YYEuropean Research CouncilDutch Research Council (NWO)Wellcome TrustThe Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.2 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, detmedRxiv : the preprint server for health sciences2024.12.03.24317000https://www.ebi.ac.uk/biostudies/studies/S-EPMC11643159biostudies-literatureAlzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset.PMC11643159340755175.010.200047.017.043Wheeler NRMena PRWhite HRen YBass LKatanic ZNaj ACWang HSchellenberg GDZhao YCheng PLCuccaro MHaines JLPericak-Vance MAValladares ONicaretta HMartin EQu LFarrer LAKuksa PPCarter LJin JVardarajan BNMayeux RPLee WPKirsch MWang LSSaravanan NGreenfest-Allen EHohman TJZhu CAlzheimer’s Disease Sequencing ProjectKunkle BWKuzma ABDalgard CTurner SLBush WSCantwell LIqbal TGunasekaran TIToga AZhang XLeung YYFarrell JJGangadharan PfalseAlzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset.The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.2 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, det2024-01-01T00:00:00Z2024 Dec2025-04-27T00:27:31.269Z2025-04-06T17:50:42.725ZS-EPMC116431593967746410.1101/2024.12.03.24317000