{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Abosheaishaa H"],"pubmed_abstract":["Introduction
Endoscopic submucosal dissection (ESD) allows for curative en-bloc resection of dysplastic gastrointestinal (GI) tract lesions. However, it is associated with postoperative adverse events (AEs) such as pain, bleeding, and perforation. Dexmedetomidine, an α2-receptor agonist, has emerged as a promising adjunct sedative for ESD under moderate sedation, offering anxiolysis and analgesia. We conducted a systematic review and meta-analysis to evaluate its efficacy and safety for use in ESD.Methods
A comprehensive systematic search was conducted across multiple databases, including Embase, Medline, Scopus, and Web of Science. Studies that involved ESD utilizing dexmedetomidine as an adjunctive medication in combination with other sedatives, were included. Data extrac"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.11.14.24317324"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11643290"],"repository":["biostudies-literature"],"pubmed_title":["Dexmedetomidine as an Adjunctive Sedative in Patients Undergoing Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis."],"pmcid":["PMC11643290"],"pubmed_authors":["Mohamed D","Nassar M","Aboeldahb M","Ismail A","Mohamed I","Abosheaishaa H","Sethi A","Azzam AY","Abdelghany A","Altschul DJ","Bilal M","Abdelhalim O","Abdallfatah A","Essibayi MA"],"additional_accession":[]},"is_claimable":false,"name":"Dexmedetomidine as an Adjunctive Sedative in Patients Undergoing Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis.","description":"Introduction
Endoscopic submucosal dissection (ESD) allows for curative en-bloc resection of dysplastic gastrointestinal (GI) tract lesions. However, it is associated with postoperative adverse events (AEs) such as pain, bleeding, and perforation. Dexmedetomidine, an α2-receptor agonist, has emerged as a promising adjunct sedative for ESD under moderate sedation, offering anxiolysis and analgesia. We conducted a systematic review and meta-analysis to evaluate its efficacy and safety for use in ESD.Methods
A comprehensive systematic search was conducted across multiple databases, including Embase, Medline, Scopus, and Web of Science. Studies that involved ESD utilizing dexmedetomidine as an adjunctive medication in combination with other sedatives, were included. Data extrac","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-18T14:23:23.713Z","creation":"2025-04-07T00:32:07.923Z"},"accession":"S-EPMC11643290","cross_references":{"pubmed":["39677437"],"doi":["10.1101/2024.11.14.24317324"]}}