biostudies-literatureAglipay MCanadian Immunity Task ForceCIHR913-923https://www.ebi.ac.uk/biostudies/studies/S-EPMC11644124biostudies-literatureUnknown115(6)<h4>Objective</h4>Characterizing the seroprevalence of SARS-CoV-2 antibodies in children is needed to optimize the COVID-19 public health response. We quantified the seroprevalence of SARS-CoV-2 infection-acquired antibodies and vaccine-acquired antibodies among children receiving primary care in Toronto, Canada.<h4>Methods</h4>We conducted a longitudinal cohort study between January 2021 and November 2022 in healthy children aged 0-16 years receiving primary care in Toronto. The primary and secondary outcomes were seroprevalence of SARS-COV-2 infection-acquired antibodies and vaccine-acquired antibodies ascertained from finger-prick dried blood spots. Samples were tested using an enzyme-linked immunosorbent assay for antibodies to full-length spike trimer and nucleocapsid. We explored socCanadian journal of public health = Revue canadienne de sante publiqueSeroprevalence of SARS-CoV-2 antibodies among children receiving primary care in Toronto, Ontario.PMC11644124468613Tursun TPersaud NMalick AClark JDurocher YYoung EBegum EAMaguire JTuite ANasser SRodrigues MPorepa MAbraham EOwen JStewart KJansz GYing ELakhanpal GTaylor CSgro MGrewal KRaso PGuiang CCraig AKnowles HParkin PChan JHanson LRaza DSocynska IShepherd SDo AYaremko JAnderson LNJacobson SMailhot GAssan RNash KLebovic GKwok BDe Guerra VArafeh DStern DBondar HWeir SStitt ABustos MReid-Westoby CRhodes MSaunderson JZaccaria MQi VOfford AKim JConstantin EGazeley SMoodie RDjolovic AOgwuru MCarsley SD'Hollander CPabon TGringas ACCalpin CHarrington LFreeman SDe Castris-Garcia KLi AYoshida-Montezuma YKelleher SDerocher MBLakhoo STurner SEgger ASiam FKandel RJagiello LZajdman MCheng EWong Pvan den Heuvel MMitchell MKadar PArbess GColwill KMarquez SAllen CPeer MBaker JQi FJaleel MBirken CTavares ESCost KGingras ACVanderhout SShuja HVanderloo LDoukas KMamdani MColford MFuller ASkelding JLahiry PBonifacio JThompson JShin JNnorom ISSrikanthan CLam-Antoniades MThorpe KSchiralli VJanus MTreherne SShaibu HLeung FHRuderman CKeiswetter LKeown-Stoneman CLi PFreedman ALi XFarber APinto AGarcia AWeisdorf TTARGet Kids! CollaborationCheema SMok EKiran TDharman SMeret ADelgado-Brand MDanayan KBarozzino TDas PHandford CPerlmutar MBowry AKurt KKwong JCOmand JAMcFarlane NLRamji NBorkhoff CMFlores PRHa DRouleau KBloch GThadani SUddin FSalsa RDuku EAglipay MAnderson KMale RBayoumi IKinlin LCampbell DThompson LAli SLeduc DLau EBatten JJuni PBergeron SChisamore BfalseSeroprevalence of SARS-CoV-2 antibodies among children receiving primary care in Toronto, Ontario.<h4>Objective</h4>Characterizing the seroprevalence of SARS-CoV-2 antibodies in children is needed to optimize the COVID-19 public health response. We quantified the seroprevalence of SARS-CoV-2 infection-acquired antibodies and vaccine-acquired antibodies among children receiving primary care in Toronto, Canada.<h4>Methods</h4>We conducted a longitudinal cohort study between January 2021 and November 2022 in healthy children aged 0-16 years receiving primary care in Toronto. The primary and secondary outcomes were seroprevalence of SARS-COV-2 infection-acquired antibodies and vaccine-acquired antibodies ascertained from finger-prick dried blood spots. Samples were tested using an enzyme-linked immunosorbent assay for antibodies to full-length spike trimer and nucleocapsid. We explored soc2024-01-01T00:00:00Z2024 Dec2026-05-13T16:08:07.442Z2026-04-27T03:08:39.126ZS-EPMC116441243916896210.17269/s41997-024-00916-3