{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nyirenda J"],"funding":["FIC NIH HHS","Medical Research Council","Gates Foundation","Wellcome Trust"],"pagination":["3765-3777"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11645280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(12)"],"pubmed_abstract":["Postmortem single-cell studies have transformed understanding of lower respiratory tract diseases (LRTDs), including coronavirus disease 2019 (COVID-19), but there are minimal data from African settings where HIV, malaria and other environmental exposures may affect disease pathobiology and treatment targets. In this study, we used histology and high-dimensional imaging to characterize fatal lung disease in Malawian adults with (n = 9) and without (n = 7) COVID-19, and we generated single-cell transcriptomics data from lung, blood and nasal cells. Data integration with other cohorts showed a conserved COVID-19 histopathological signature, driven by contrasting immune and inflammatory mechanisms: in US, European and Asian cohorts, by type I/III interferon (IFN) responses, particularly in bl"],"journal":["Nature medicine"],"pubmed_title":["Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population."],"pmcid":["PMC11645280"],"funding_grant_id":["MR/W018802/1","K01 TW010853","MR/V025856/1","MR/R010099/1","INV-018138","104111"],"pubmed_authors":["Banda P","Otto TD","Mvaya L","Suwedi L","Makwinja C","Phiri C","Herder V","Hilton O","Namalima TR","Khoswe S","Nyirenda J","Silva Filho JD","Phiri J","Johnson C","Nyasulu W","Melo GC","Monteiro WM","Denno DM","Kamiza SB","Hardy OM","Marti M","Palmarini M","Voskuijl W","Barnes KG","Ziwoya F","Morton B","Ferreira LCL","Chasweka D","Ngulube T","Dos Reis MF","Moxon CA","Trindade Maranhao Costa F","McGuinness D","Eneya C","Lawrence S","Nyirenda D","Jambo K","Siwombo M","Attipa C","Ndovi C","Ilia G","de Lacerda MVG","Tembo A","Makwangwala K","Kumwenda B","Haley M","Couper K"],"additional_accession":[]},"is_claimable":false,"name":"Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population.","description":"Postmortem single-cell studies have transformed understanding of lower respiratory tract diseases (LRTDs), including coronavirus disease 2019 (COVID-19), but there are minimal data from African settings where HIV, malaria and other environmental exposures may affect disease pathobiology and treatment targets. In this study, we used histology and high-dimensional imaging to characterize fatal lung disease in Malawian adults with (n = 9) and without (n = 7) COVID-19, and we generated single-cell transcriptomics data from lung, blood and nasal cells. Data integration with other cohorts showed a conserved COVID-19 histopathological signature, driven by contrasting immune and inflammatory mechanisms: in US, European and Asian cohorts, by type I/III interferon (IFN) responses, particularly in bl","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-02T10:45:50.87Z","creation":"2025-04-04T01:54:57.036Z"},"accession":"S-EPMC11645280","cross_references":{"pubmed":["39567718"],"doi":["10.1038/s41591-024-03354-3"]}}