biostudies-literatureUnknown61(1)Alcicek SElse Kröner-Fresenius-Stiftung (EKFS)Deutsche KrebshilfeMildred Scheel Career Center Frankfurt (Deutsche Krebshilfe)Else Kröner-Fresenius-StiftungLOEWE grant within the CePTER Consortium<h4>Background</h4>Emerging evidence suggests that fasting could play a key role in cancer treatment. Its metabolic effects on gliomas require further investigation.<h4>Purpose</h4>To design a multi-voxel ¹H/³¹P MR-spectroscopic imaging (MRSI) protocol for noninvasive metabolic monitoring of cerebral, fasting-induced changes on an individual patient/tumor level, and to assess its technical reliability/reproducibility.<h4>Study type</h4>Prospective.<h4>Population</h4>MRS phantom. Twenty-two patients (mean age = 61, 6 female) with suspected WHO grade II-IV glioma examined before and after 72-hour-fasting prior to biopsy/resection.<h4>Field strength/sequence</h4>3-T, ¹H decoupled 3D ³¹P MRSI, 2D ¹H sLASER MRSI at an echo time of 144 msec,Journal of magnetic resonance imaging : JMRI426-438https://www.ebi.ac.uk/biostudies/studies/S-EPMC11645487biostudies-literature2D ¹H sLASER Long-TE and 3D ³¹P Chemical Shift Imaging at 3 T for Monitoring Fasting-Induced Changes in Brain Tumor Tissue.PMC11645487Ronellenfitsch MWWeber KJDive IThomas DCPilatus UWenger KJCzabanka MSteinbach JPHattingen EForster MTAlcicek SPrinz Vfalse2D ¹H sLASER Long-TE and 3D ³¹P Chemical Shift Imaging at 3 T for Monitoring Fasting-Induced Changes in Brain Tumor Tissue.<h4>Background</h4>Emerging evidence suggests that fasting could play a key role in cancer treatment. Its metabolic effects on gliomas require further investigation.<h4>Purpose</h4>To design a multi-voxel ¹H/³¹P MR-spectroscopic imaging (MRSI) protocol for noninvasive metabolic monitoring of cerebral, fasting-induced changes on an individual patient/tumor level, and to assess its technical reliability/reproducibility.<h4>Study type</h4>Prospective.<h4>Population</h4>MRS phantom. Twenty-two patients (mean age = 61, 6 female) with suspected WHO grade II-IV glioma examined before and after 72-hour-fasting prior to biopsy/resection.<h4>Field strength/sequence</h4>3-T, ¹H decoupled 3D ³¹P MRSI, 2D ¹H sLASER MRSI at an echo time of 144 msec,2025-01-01T00:00:00Z2025 Jan2026-07-15T08:13:16.635Z2025-04-04T01:54:58.019ZS-EPMC116454873872204310.1002/jmri.29422