biostudies-literatureUnknown16(11)Shu H<h4>Background</h4>Cancer remains one of the leading causes of mortality worldwide, characterized by uncontrolled cell proliferation and metastasis. Protein Inhibitor of Activated STAT (PIAS) family genes, comprising PIAS1, PIAS2, PIAS3, and PIAS4, are emerging as significant players in cancer biology due to their roles in SUMOylation, transcriptional regulation, and modulation of signal transduction pathways. This study provides a comprehensive analysis of PIAS family genes from a pan-cancer viewpoint.<h4>Methodology</h4>Detailed in silico analyses using publicly available databases and in vitro analyses involving cell culture, gene knockdown, colony formation, and wound healing assays.<h4>Results</h4>Expression analysis revealed consistent up-regulation of PIAS1, PIAS2, PIAS3, and PIAS4 American journal of translational research6346-6364https://www.ebi.ac.uk/biostudies/studies/S-EPMC11645565biostudies-literaturePIAS family gene expression: implications for prognosis, immunomodulation, and chemotherapy response.PMC11645565Li PShu HChen XZhao JSun ZfalsePIAS family gene expression: implications for prognosis, immunomodulation, and chemotherapy response.<h4>Background</h4>Cancer remains one of the leading causes of mortality worldwide, characterized by uncontrolled cell proliferation and metastasis. Protein Inhibitor of Activated STAT (PIAS) family genes, comprising PIAS1, PIAS2, PIAS3, and PIAS4, are emerging as significant players in cancer biology due to their roles in SUMOylation, transcriptional regulation, and modulation of signal transduction pathways. This study provides a comprehensive analysis of PIAS family genes from a pan-cancer viewpoint.<h4>Methodology</h4>Detailed in silico analyses using publicly available databases and in vitro analyses involving cell culture, gene knockdown, colony formation, and wound healing assays.<h4>Results</h4>Expression analysis revealed consistent up-regulation of PIAS1, PIAS2, PIAS3, and PIAS4 2024-01-01T00:00:00Z20242025-04-04T01:36:21.056Z2025-04-04T01:36:21.056ZS-EPMC116455653967859510.62347/JRDP401810.62347/jrdp4018