{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(12)"],"submitter":["Tartof SY"],"pubmed_abstract":["<h4>Importance</h4>Clinical trials have demonstrated high vaccine efficacy (VE) against lower respiratory tract disease (LRTD) but enrolled a smaller proportion of persons aged 75 years or older and those with comorbidities than seen in highest-risk populations in clinical practice settings. Additionally, VE against respiratory syncytial virus (RSV)-related hospitalizations and emergency department (ED) visits is not yet fully described.<h4>Objective</h4>To estimate Respiratory Syncytial Virus Prefusion F (RSVpreF) effectiveness in older adults.<h4>Design, setting, and participants</h4>This was a retrospective case-control study with a test negative design. Cases were adults aged 60 years or older with hospitalizations or ED visits at Kaiser Permanente of Southern California for LRTD from "],"journal":["JAMA network open"],"pagination":["e2450832"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11645642"],"repository":["biostudies-literature"],"pubmed_title":["Estimated Vaccine Effectiveness for Respiratory Syncytial Virus-Related Lower Respiratory Tract Disease."],"pmcid":["PMC11645642"],"pubmed_authors":["Chia B","Slezak J","Spence BC","Kapadia B","Aliabadi N","Liu Q","Tartof SY","Chilson E","Begier E","Aragones M","Dutro M","Davis GS","Gessner BD","Stern JA","Gonzalez E","Goodwin G","Lewnard JA","Shaw S","Welsh S","Hong V","Jodar L","Hubler R","Ackerson B"],"additional_accession":[]},"is_claimable":false,"name":"Estimated Vaccine Effectiveness for Respiratory Syncytial Virus-Related Lower Respiratory Tract Disease.","description":"<h4>Importance</h4>Clinical trials have demonstrated high vaccine efficacy (VE) against lower respiratory tract disease (LRTD) but enrolled a smaller proportion of persons aged 75 years or older and those with comorbidities than seen in highest-risk populations in clinical practice settings. Additionally, VE against respiratory syncytial virus (RSV)-related hospitalizations and emergency department (ED) visits is not yet fully described.<h4>Objective</h4>To estimate Respiratory Syncytial Virus Prefusion F (RSVpreF) effectiveness in older adults.<h4>Design, setting, and participants</h4>This was a retrospective case-control study with a test negative design. Cases were adults aged 60 years or older with hospitalizations or ED visits at Kaiser Permanente of Southern California for LRTD from ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-07-15T01:44:36.139Z","creation":"2025-04-04T02:30:29.895Z"},"accession":"S-EPMC11645642","cross_references":{"pubmed":["39671195"],"doi":["10.1001/jamanetworkopen.2024.50832"]}}