biostudies-literatureUnknown7(12)Tartof SY<h4>Importance</h4>Clinical trials have demonstrated high vaccine efficacy (VE) against lower respiratory tract disease (LRTD) but enrolled a smaller proportion of persons aged 75 years or older and those with comorbidities than seen in highest-risk populations in clinical practice settings. Additionally, VE against respiratory syncytial virus (RSV)-related hospitalizations and emergency department (ED) visits is not yet fully described.<h4>Objective</h4>To estimate Respiratory Syncytial Virus Prefusion F (RSVpreF) effectiveness in older adults.<h4>Design, setting, and participants</h4>This was a retrospective case-control study with a test negative design. Cases were adults aged 60 years or older with hospitalizations or ED visits at Kaiser Permanente of Southern California for LRTD from JAMA network opene2450832https://www.ebi.ac.uk/biostudies/studies/S-EPMC11645642biostudies-literatureEstimated Vaccine Effectiveness for Respiratory Syncytial Virus-Related Lower Respiratory Tract Disease.PMC11645642Chia BSlezak JSpence BCKapadia BAliabadi NLiu QTartof SYChilson EBegier EAragones MDutro MDavis GSGessner BDStern JAGonzalez EGoodwin GLewnard JAShaw SWelsh SHong VJodar LHubler RAckerson BfalseEstimated Vaccine Effectiveness for Respiratory Syncytial Virus-Related Lower Respiratory Tract Disease.<h4>Importance</h4>Clinical trials have demonstrated high vaccine efficacy (VE) against lower respiratory tract disease (LRTD) but enrolled a smaller proportion of persons aged 75 years or older and those with comorbidities than seen in highest-risk populations in clinical practice settings. Additionally, VE against respiratory syncytial virus (RSV)-related hospitalizations and emergency department (ED) visits is not yet fully described.<h4>Objective</h4>To estimate Respiratory Syncytial Virus Prefusion F (RSVpreF) effectiveness in older adults.<h4>Design, setting, and participants</h4>This was a retrospective case-control study with a test negative design. Cases were adults aged 60 years or older with hospitalizations or ED visits at Kaiser Permanente of Southern California for LRTD from 2024-01-01T00:00:00Z2024 Dec2026-07-15T01:44:36.139Z2025-04-04T02:30:29.895ZS-EPMC116456423967119510.1001/jamanetworkopen.2024.50832