{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(6)"],"submitter":["Li Y"],"pubmed_abstract":["<h4>Background</h4>Arthritis is a degenerative joint disease influenced by various environmental factors, including exposure to Benzophenone-3 (BP3), a common UV filter. This study aims to elucidate the toxicological impact of BP3 on arthritis pathogenesis using network toxicology approaches.<h4>Method</h4>We integrated data from the Comparative Toxicogenomics Database (CTD) and Gene Expression Omnibus (GEO) to identify differentially expressed BP3-related toxicological targets in osteoarthritis (OA). Enrichment analyses were conducted to determine the implicated biological processes, cellular components, and molecular functions. Further, the involvement of the PI3K-Akt signaling pathway was investigated, along with correlations with immune cell infiltration and immune-related pathways. Mo"],"journal":["Toxicology research"],"pagination":["tfae199"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11645663"],"repository":["biostudies-literature"],"pubmed_title":["The impact of Benzophenone-3 on osteoarthritis pathogenesis: a network toxicology approach."],"pmcid":["PMC11645663"],"pubmed_authors":["Yang X","Liu H","Li Y","Hu H","Liu P","Wang G","Zhang L"],"additional_accession":[]},"is_claimable":false,"name":"The impact of Benzophenone-3 on osteoarthritis pathogenesis: a network toxicology approach.","description":"<h4>Background</h4>Arthritis is a degenerative joint disease influenced by various environmental factors, including exposure to Benzophenone-3 (BP3), a common UV filter. This study aims to elucidate the toxicological impact of BP3 on arthritis pathogenesis using network toxicology approaches.<h4>Method</h4>We integrated data from the Comparative Toxicogenomics Database (CTD) and Gene Expression Omnibus (GEO) to identify differentially expressed BP3-related toxicological targets in osteoarthritis (OA). Enrichment analyses were conducted to determine the implicated biological processes, cellular components, and molecular functions. Further, the involvement of the PI3K-Akt signaling pathway was investigated, along with correlations with immune cell infiltration and immune-related pathways. Mo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-06T14:35:07.217Z","creation":"2026-05-31T03:09:59.897Z"},"accession":"S-EPMC11645663","cross_references":{"pubmed":["39677492"],"doi":["10.1093/toxres/tfae199"]}}