biostudies-literatureUnknown13(6)Li Y<h4>Background</h4>Arthritis is a degenerative joint disease influenced by various environmental factors, including exposure to Benzophenone-3 (BP3), a common UV filter. This study aims to elucidate the toxicological impact of BP3 on arthritis pathogenesis using network toxicology approaches.<h4>Method</h4>We integrated data from the Comparative Toxicogenomics Database (CTD) and Gene Expression Omnibus (GEO) to identify differentially expressed BP3-related toxicological targets in osteoarthritis (OA). Enrichment analyses were conducted to determine the implicated biological processes, cellular components, and molecular functions. Further, the involvement of the PI3K-Akt signaling pathway was investigated, along with correlations with immune cell infiltration and immune-related pathways. MoToxicology researchtfae199https://www.ebi.ac.uk/biostudies/studies/S-EPMC11645663biostudies-literatureThe impact of Benzophenone-3 on osteoarthritis pathogenesis: a network toxicology approach.PMC11645663Yang XLiu HLi YHu HLiu PWang GZhang LfalseThe impact of Benzophenone-3 on osteoarthritis pathogenesis: a network toxicology approach.<h4>Background</h4>Arthritis is a degenerative joint disease influenced by various environmental factors, including exposure to Benzophenone-3 (BP3), a common UV filter. This study aims to elucidate the toxicological impact of BP3 on arthritis pathogenesis using network toxicology approaches.<h4>Method</h4>We integrated data from the Comparative Toxicogenomics Database (CTD) and Gene Expression Omnibus (GEO) to identify differentially expressed BP3-related toxicological targets in osteoarthritis (OA). Enrichment analyses were conducted to determine the implicated biological processes, cellular components, and molecular functions. Further, the involvement of the PI3K-Akt signaling pathway was investigated, along with correlations with immune cell infiltration and immune-related pathways. Mo2024-01-01T00:00:00Z2024 Dec2026-06-06T14:35:07.217Z2026-05-31T03:09:59.897ZS-EPMC116456633967749210.1093/toxres/tfae199