{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(12)"],"submitter":["Tian B"],"pubmed_abstract":["<h4>Background</h4>Coronary heart disease (CHD) represents a significant global health concern, arising from an intricate interplay between genetic predisposition and environmental influences, with a pivotal involvement of oxidized low-density lipoprotein (ox-LDL) in the pathophysiology of it. We aimed to elucidate the synergistic dynamics of B cell activating transcription factor (BATF) and Sirtuin 1 (SIRT1) in cell injury caused by ox-LDL, reveal potential therapeutic strategies for CHD.<h4>Methods</h4>The GSE42148 dataset was used to analyze Differentially expressed genes (DEGs) to construct a gene co-expression network. Then bioinformatics analysis was performed on key modules to select the BATF gene. In vitro experiments were conducted to investigate the protective impact of BATF agai"],"journal":["PloS one"],"pagination":["e0306514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11649077"],"repository":["biostudies-literature"],"pubmed_title":["BATF alleviates ox-LDL-induced HCAEC injury by regulating SIRT1 expression in coronary heart disease."],"pmcid":["PMC11649077"],"pubmed_authors":["Jin C","Tian B","Ji J"],"additional_accession":[]},"is_claimable":false,"name":"BATF alleviates ox-LDL-induced HCAEC injury by regulating SIRT1 expression in coronary heart disease.","description":"<h4>Background</h4>Coronary heart disease (CHD) represents a significant global health concern, arising from an intricate interplay between genetic predisposition and environmental influences, with a pivotal involvement of oxidized low-density lipoprotein (ox-LDL) in the pathophysiology of it. We aimed to elucidate the synergistic dynamics of B cell activating transcription factor (BATF) and Sirtuin 1 (SIRT1) in cell injury caused by ox-LDL, reveal potential therapeutic strategies for CHD.<h4>Methods</h4>The GSE42148 dataset was used to analyze Differentially expressed genes (DEGs) to construct a gene co-expression network. Then bioinformatics analysis was performed on key modules to select the BATF gene. In vitro experiments were conducted to investigate the protective impact of BATF agai","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T01:50:50.127Z","creation":"2025-04-04T01:50:50.127Z"},"accession":"S-EPMC11649077","cross_references":{"pubmed":["39680523"],"doi":["10.1371/journal.pone.0306514"]}}