biostudies-literatureUnknown19(12)Tian B<h4>Background</h4>Coronary heart disease (CHD) represents a significant global health concern, arising from an intricate interplay between genetic predisposition and environmental influences, with a pivotal involvement of oxidized low-density lipoprotein (ox-LDL) in the pathophysiology of it. We aimed to elucidate the synergistic dynamics of B cell activating transcription factor (BATF) and Sirtuin 1 (SIRT1) in cell injury caused by ox-LDL, reveal potential therapeutic strategies for CHD.<h4>Methods</h4>The GSE42148 dataset was used to analyze Differentially expressed genes (DEGs) to construct a gene co-expression network. Then bioinformatics analysis was performed on key modules to select the BATF gene. In vitro experiments were conducted to investigate the protective impact of BATF agaiPloS onee0306514https://www.ebi.ac.uk/biostudies/studies/S-EPMC11649077biostudies-literatureBATF alleviates ox-LDL-induced HCAEC injury by regulating SIRT1 expression in coronary heart disease.PMC11649077Jin CTian BJi JfalseBATF alleviates ox-LDL-induced HCAEC injury by regulating SIRT1 expression in coronary heart disease.<h4>Background</h4>Coronary heart disease (CHD) represents a significant global health concern, arising from an intricate interplay between genetic predisposition and environmental influences, with a pivotal involvement of oxidized low-density lipoprotein (ox-LDL) in the pathophysiology of it. We aimed to elucidate the synergistic dynamics of B cell activating transcription factor (BATF) and Sirtuin 1 (SIRT1) in cell injury caused by ox-LDL, reveal potential therapeutic strategies for CHD.<h4>Methods</h4>The GSE42148 dataset was used to analyze Differentially expressed genes (DEGs) to construct a gene co-expression network. Then bioinformatics analysis was performed on key modules to select the BATF gene. In vitro experiments were conducted to investigate the protective impact of BATF agai2024-01-01T00:00:00Z20242025-04-04T01:50:50.127Z2025-04-04T01:50:50.127ZS-EPMC116490773968052310.1371/journal.pone.0306514