biostudies-literatureBennett JBritish Heart Foundatione017425https://www.ebi.ac.uk/biostudies/studies/S-EPMC11649182biostudies-literatureUnknown17(12)<h4>Background</h4>In aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. Following aortic valve replacement (AVR), left ventricular hypertrophy regression occurs, but early cellular and extracellular dynamics are unknown.<h4>Methods</h4>Patients with severe symptomatic aortic stenosis undergoing surgical or transcatheter AVR were prospectively recruited. Pre- and early post-AVR cardiac magnetic resonance imaging assessed left ventricular remodeling, global longitudinal strain, and T1 mapping to determine extracellular volume fraction and volume of cellular and extracellular compartments.<h4>Results</h4>In all, 39 patients (aged 71.4±9.8 years, mCirculation. Cardiovascular imagingLeft Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement.PMC11649182FS/19/35/34374FS/CRTF/21/24128Nitsche CManisty COzkor MBhattacharyya SMravljak ROo AYates MShipolini AKennon SPierce ISheikh AGul UDi Salvo CLopez-Marco MAAwad WDavies RHBarts Valve and Imaging GroupUppal RLawrence DGama FFThornton GDMoon JCKolvekar SYap JAdams BAktuerk DKellman PAmbekar SBennett JShetye AWong PKBaumbach ATreibel TALloyd GRoberts NAziminia NLall KMullen MMathur AfalseLeft Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement.<h4>Background</h4>In aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. Following aortic valve replacement (AVR), left ventricular hypertrophy regression occurs, but early cellular and extracellular dynamics are unknown.<h4>Methods</h4>Patients with severe symptomatic aortic stenosis undergoing surgical or transcatheter AVR were prospectively recruited. Pre- and early post-AVR cardiac magnetic resonance imaging assessed left ventricular remodeling, global longitudinal strain, and T1 mapping to determine extracellular volume fraction and volume of cellular and extracellular compartments.<h4>Results</h4>In all, 39 patients (aged 71.4±9.8 years, m2024-01-01T00:00:00Z2024 Dec2026-06-01T12:12:15.523Z2026-04-08T12:07:47.47ZS-EPMC116491823962958610.1161/CIRCIMAGING.124.017425