biostudies-literatureUnknownKendler KS<h4>Background</h4>Drug use Disorder (DUD), the risk for which is substantially influenced by both genetic and social factors, is geographically concentrated in high-risk regions. An important step toward understanding this pattern is to examine geographical distributions of the genetic liability to DUD and a key demographic risk factor - social deprivation.<h4>Methods</h4>We calculated the mean family genetic risk score (FGRS) for DUD ((FGRS_DUD) and social deprivation for each of the 5983 areas Demographic Statistical Areas (DeSO) for all of Sweden and used geospatial techniques to analyze and map these factors.<h4>Results</h4>Using 2018 data, substantial spatial heterogeneity was seen in the distribution of the genetic risk for DUD in Sweden as a whole and in its three major uPsychological medicine1-10https://www.ebi.ac.uk/biostudies/studies/S-EPMC11650187biostudies-literatureThe geographical distribution of the family-genetic risk score for drug use disorder in Sweden and its co-localization with areas of social deprivation.PMC11650187Sundquist JStewart KSundquist KOhlsson HMalmberg BZhao PMansourian AKendler KSfalseThe geographical distribution of the family-genetic risk score for drug use disorder in Sweden and its co-localization with areas of social deprivation.<h4>Background</h4>Drug use Disorder (DUD), the risk for which is substantially influenced by both genetic and social factors, is geographically concentrated in high-risk regions. An important step toward understanding this pattern is to examine geographical distributions of the genetic liability to DUD and a key demographic risk factor - social deprivation.<h4>Methods</h4>We calculated the mean family genetic risk score (FGRS) for DUD ((FGRS_DUD) and social deprivation for each of the 5983 areas Demographic Statistical Areas (DeSO) for all of Sweden and used geospatial techniques to analyze and map these factors.<h4>Results</h4>Using 2018 data, substantial spatial heterogeneity was seen in the distribution of the genetic risk for DUD in Sweden as a whole and in its three major u2024-01-01T00:00:00Z2024 Dec2025-04-18T14:21:24.163Z2025-04-04T21:44:55.379ZS-EPMC116501873961833010.1017/S0033291724002745