biostudies-literatureUnknown24(6)Levy IThe American cockroach Periplaneta americana (L.) (Blattodea, Blattidae) has been a model organism for biochemical and physiological study for almost a century, however, its use does not benefit from the genetic tools found in key model species such as Drosophila melanogaster. To facilitate the use of the cockroach as a model system in neuroscience and to serve as a foundation for functional and translational experimentation, a transcriptome of the cephalic ganglia was assembled and annotated, and differential expression profiles between these ganglia were assessed. The transcriptome assembly yielded >400 k transcripts, with >40 k putative coding sequences. Gene ontology and protein domain searches indicate the cerebral and gnathal ganglia (GNG) have distinct genetic expression profiles. TJournal of insect science (Online)12https://www.ebi.ac.uk/biostudies/studies/S-EPMC11650548biostudies-literatureCephalic ganglia transcriptomics of the American cockroach Periplaneta americana (Blattodea: Blattidae).PMC11650548Arvidson RLevy IfalseCephalic ganglia transcriptomics of the American cockroach Periplaneta americana (Blattodea: Blattidae).The American cockroach Periplaneta americana (L.) (Blattodea, Blattidae) has been a model organism for biochemical and physiological study for almost a century, however, its use does not benefit from the genetic tools found in key model species such as Drosophila melanogaster. To facilitate the use of the cockroach as a model system in neuroscience and to serve as a foundation for functional and translational experimentation, a transcriptome of the cephalic ganglia was assembled and annotated, and differential expression profiles between these ganglia were assessed. The transcriptome assembly yielded >400 k transcripts, with >40 k putative coding sequences. Gene ontology and protein domain searches indicate the cerebral and gnathal ganglia (GNG) have distinct genetic expression profiles. T2024-01-01T00:00:00Z2024 Nov2026-06-03T05:25:18.44Z2025-04-04T21:09:51.386ZS-EPMC116505483968838210.1093/jisesa/ieae113