{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang WK"],"funding":["U.S. Department of Health &amp; Human Services | NIH | National Institute of General Medical Sciences","U.S. Department of Health &amp; Human Services | NIH | National Institute of Neurological Disorders and Stroke","NIDDK NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)","NIGMS NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["72-85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11650697"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["A growing body of evidence indicates that gut microbiota influence brain function and behaviour. However, the molecular basis of how gut bacteria modulate host nervous system function is largely unknown. Here we show that vitamin B<sub>12</sub>-producing bacteria that colonize the intestine can modulate excitatory cholinergic signalling and behaviour in the host Caenorhabditis elegans. Here we demonstrate that vitamin B<sub>12</sub> reduces cholinergic signalling in the nervous system through rewiring of the methionine (Met)/S-adenosylmethionine cycle in the intestine. We identify a conserved metabolic crosstalk between the methionine/S-adenosylmethionine cycle and the choline-oxidation pathway. In addition, we show that metabolic rewiring of these pathways by vitamin B<sub>12</sub> reduce"],"journal":["Nature cell biology"],"pubmed_title":["Vitamin B<sub>12</sub> produced by gut bacteria modulates cholinergic signalling."],"pmcid":["PMC11650697"],"funding_grant_id":["NS107475","R35 GM131877","R01 DK068429","GM131877","DK068429"],"pubmed_authors":["Fox BW","Thackeray A","Kang WK","Araya A","Schroeder FC","Alkema MJ","Walhout AJM","Florman JT"],"additional_accession":[]},"is_claimable":false,"name":"Vitamin B<sub>12</sub> produced by gut bacteria modulates cholinergic signalling.","description":"A growing body of evidence indicates that gut microbiota influence brain function and behaviour. However, the molecular basis of how gut bacteria modulate host nervous system function is largely unknown. Here we show that vitamin B<sub>12</sub>-producing bacteria that colonize the intestine can modulate excitatory cholinergic signalling and behaviour in the host Caenorhabditis elegans. Here we demonstrate that vitamin B<sub>12</sub> reduces cholinergic signalling in the nervous system through rewiring of the methionine (Met)/S-adenosylmethionine cycle in the intestine. We identify a conserved metabolic crosstalk between the methionine/S-adenosylmethionine cycle and the choline-oxidation pathway. In addition, we show that metabolic rewiring of these pathways by vitamin B<sub>12</sub> reduce","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-27T00:25:37.78Z","creation":"2025-04-06T17:55:18.15Z"},"accession":"S-EPMC11650697","cross_references":{"pubmed":["38168768"],"doi":["10.1038/s41556-023-01299-2"]}}