{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tveit Solheim E"],"funding":["Gerda Meyer Nyquist Gulbranson & Gerdt Meyer Nyquist Legacy"],"pagination":["3255-3266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11651201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(12)"],"pubmed_abstract":["<h4>Objective</h4>Patients with ovarian cancer (OC) may develop anti-Yo-associated paraneoplastic cerebellar degeneration (PCD)-a cerebellar ataxia associated with tumor-induced autoimmunity against CDR2 and CDR2L proteins. Dysregulation of circulating exosomal microRNAs (miRNAs) occur in OC. Here, we investigated whether PCD is associated with changes in the exosomal miRNA profiles of OC patients.<h4>Methods</h4>Serum exosomes were isolated from patients with OC (n = 15), patients with OC and anti-Yo-associated PCD (n = 14) and healthy controls (HC, n = 15). Small RNA sequencing was used to identify differentially expressed miRNAs. Receiver operating characteristic curves were used to evaluate biomarker sensitivity and specificity, and miRNA target prediction analysis was employed to eluc"],"journal":["Annals of clinical and translational neurology"],"pubmed_title":["Altered exosomal miRNA profiles in patients with paraneoplastic cerebellar degeneration."],"pmcid":["PMC11651201"],"funding_grant_id":["102230101"],"pubmed_authors":["Vedeler CA","Desestret V","Tveit Solheim E","Bjorge L","Totland C","Anandan S","Vestrheim Thomsen LC","Peter E"],"additional_accession":[]},"is_claimable":false,"name":"Altered exosomal miRNA profiles in patients with paraneoplastic cerebellar degeneration.","description":"<h4>Objective</h4>Patients with ovarian cancer (OC) may develop anti-Yo-associated paraneoplastic cerebellar degeneration (PCD)-a cerebellar ataxia associated with tumor-induced autoimmunity against CDR2 and CDR2L proteins. Dysregulation of circulating exosomal microRNAs (miRNAs) occur in OC. Here, we investigated whether PCD is associated with changes in the exosomal miRNA profiles of OC patients.<h4>Methods</h4>Serum exosomes were isolated from patients with OC (n = 15), patients with OC and anti-Yo-associated PCD (n = 14) and healthy controls (HC, n = 15). Small RNA sequencing was used to identify differentially expressed miRNAs. Receiver operating characteristic curves were used to evaluate biomarker sensitivity and specificity, and miRNA target prediction analysis was employed to eluc","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-18T14:40:19.618Z","creation":"2025-04-07T00:56:40.205Z"},"accession":"S-EPMC11651201","cross_references":{"pubmed":["39473143"],"doi":["10.1002/acn3.52232"]}}