{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Castelo J"],"funding":["Scientific Foundation of the Spanish Association Against Cancer in Biscay","Deutsche Forschungsgemeinschaft","FEMS Research and Training"],"pagination":["2438829"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11651279"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Phloroglucinol is a key byproduct of gut microbial metabolism that has been widely used as a treatment for irritable bowel syndrome. Here, we demonstrate that phloroglucinol tempers macrophage responses to pro-inflammatory pathogens and stimuli. <i>In vivo</i>, phloroglucinol administration decreases gut and extraintestinal inflammation in murine models of inflammatory bowel disease and systemic infection. The metabolite induces modest modifications in the microbiota. However, the presence of an active microbiota is required to preserve its anti-inflammatory activity. Remarkably, the protective effect of phloroglucinol lasts partially at least 6 months. Single-cell transcriptomic analysis of bone marrow progenitors demonstrates the capacity of the metabolite to induce long-lasting innate i"],"journal":["Gut microbes"],"pubmed_title":["The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation."],"pmcid":["PMC11651279"],"funding_grant_id":["1816","PRDVZ222452GUTI"],"pubmed_authors":["Atondo E","Margolles A","Rodriguez H","Pena-Cearra A","Castelo J","Martin Rodriguez JE","Victoria Selma M","Anguita J","Maria Flores J","Garcia-Canas V","Lavin JL","Plaza-Vinuesa L","Plata A","Cobela A","Barcena L","Martin-Ruiz I","Marcos R","Gonzalez-Lopez M","Mancheno JM","Tanner Pasco S","Santos-Fernandez E","Fernandez-Tejada A","Simo C","Maria Aransay A","Munoz R","Ruas-Madiedo P","Khamwong M","Seoane I","de Las Rivas B","Abecia L","Gutiez N","Pellon A","Barriales D","Palacios A","Villaran MC","Gomez de Aguero M","Araujo-Aris S"],"additional_accession":[]},"is_claimable":false,"name":"The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation.","description":"Phloroglucinol is a key byproduct of gut microbial metabolism that has been widely used as a treatment for irritable bowel syndrome. Here, we demonstrate that phloroglucinol tempers macrophage responses to pro-inflammatory pathogens and stimuli. <i>In vivo</i>, phloroglucinol administration decreases gut and extraintestinal inflammation in murine models of inflammatory bowel disease and systemic infection. The metabolite induces modest modifications in the microbiota. However, the presence of an active microbiota is required to preserve its anti-inflammatory activity. Remarkably, the protective effect of phloroglucinol lasts partially at least 6 months. Single-cell transcriptomic analysis of bone marrow progenitors demonstrates the capacity of the metabolite to induce long-lasting innate i","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan-Dec","modification":"2026-06-03T05:24:39.969Z","creation":"2025-04-04T01:08:59.348Z"},"accession":"S-EPMC11651279","cross_references":{"pubmed":["39676480"],"doi":["10.1080/19490976.2024.2438829"]}}