biostudies-literatureUnknown14(12)Wei S<h4>Background</h4>In the traditional computed tomography (CT) simulation process, patients need to undergo CT scans before and after injection of iodine-based contrast agent, resulting in a cumbersome workflow and additional imaging dose. Contrast-enhanced spectral CT can synthesize true contrast-enhanced (TCE) images and virtual noncontrast (VNC) images in a single scan without geometric misalignment. To improve work efficiency and reduce patients' imaging dose, we studied the feasibility of using VNC images for radiotherapy treatment planning, with true noncontrast (TNC) images as references and explored its dosimetric advantages compared to using TCE images. Specifically, this study examined tumors near bones, including cases of bone metastasis and myeloma.<h4>Methods</h4>A total of 54Quantitative imaging in medicine and surgery8443-8455https://www.ebi.ac.uk/biostudies/studies/S-EPMC11652005biostudies-literatureA feasibility study of using virtual noncontrast images synthesized from dual-energy computed tomography for radiotherapy treatment planning.PMC11652005Li WLiu XGuo MQiu JYu LWei SZhou BYang BZhu QDai JfalseA feasibility study of using virtual noncontrast images synthesized from dual-energy computed tomography for radiotherapy treatment planning.<h4>Background</h4>In the traditional computed tomography (CT) simulation process, patients need to undergo CT scans before and after injection of iodine-based contrast agent, resulting in a cumbersome workflow and additional imaging dose. Contrast-enhanced spectral CT can synthesize true contrast-enhanced (TCE) images and virtual noncontrast (VNC) images in a single scan without geometric misalignment. To improve work efficiency and reduce patients' imaging dose, we studied the feasibility of using VNC images for radiotherapy treatment planning, with true noncontrast (TNC) images as references and explored its dosimetric advantages compared to using TCE images. Specifically, this study examined tumors near bones, including cases of bone metastasis and myeloma.<h4>Methods</h4>A total of 542024-01-01T00:00:00Z2024 Dec2025-04-03T23:13:31.725Z2025-04-03T23:13:31.725ZS-EPMC116520053969865810.21037/qims-24-885