{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["69(24)"],"submitter":["Ma C"],"funding":["NIBIB NIH HHS","NCI NIH HHS","National Institutes of Health"],"pubmed_abstract":["<i>Objective.</i>We previously developed a FLASH planning framework for streamlined pin-ridge-filter (pin-RF) design, demonstrating its feasibility for single-energy proton FLASH planning. In this study, we refined the pin-RF design for easy assembly using reusable modules, focusing on its application in liver stereotactic ablative body radiotherapy (SABR).<i>Approach.</i>This framework generates an intermediate intensity-modulated proton therapy (IMPT) plan and translates it into step widths and thicknesses of pin-RFs for a single-energy FLASH plan. Parameters like energy spacing, monitor unit limit, and spot quantity were adjusted during IMPT planning, resulting in pin-RFs assembled using predefined modules with widths from 1 to 6 mm, each with a water-equivalent-thickness of 5 mm. This "],"journal":["Physics in medicine and biology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11653111"],"repository":["biostudies-literature"],"pubmed_title":["Feasibility study of modularized pin ridge filter implementation in proton FLASH planning for liver stereotactic ablative body radiotherapy."],"pmcid":["PMC11653111"],"funding_grant_id":["R01CA272991","U54 CA274513","R56EB033332","U54CA274513","R01EB032680","R01 CA272991","R01 EB032680","R56 EB033332"],"pubmed_authors":["Yang X","Patel P","Setianegara J","Ma C","Gao Y","Yu D","Wang Y","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Feasibility study of modularized pin ridge filter implementation in proton FLASH planning for liver stereotactic ablative body radiotherapy.","description":"<i>Objective.</i>We previously developed a FLASH planning framework for streamlined pin-ridge-filter (pin-RF) design, demonstrating its feasibility for single-energy proton FLASH planning. In this study, we refined the pin-RF design for easy assembly using reusable modules, focusing on its application in liver stereotactic ablative body radiotherapy (SABR).<i>Approach.</i>This framework generates an intermediate intensity-modulated proton therapy (IMPT) plan and translates it into step widths and thicknesses of pin-RFs for a single-energy FLASH plan. Parameters like energy spacing, monitor unit limit, and spot quantity were adjusted during IMPT planning, resulting in pin-RFs assembled using predefined modules with widths from 1 to 6 mm, each with a water-equivalent-thickness of 5 mm. This ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-06T14:35:14.491Z","creation":"2026-05-31T03:10:00.69Z"},"accession":"S-EPMC11653111","cross_references":{"pubmed":["39571283"],"doi":["10.1088/1361-6560/ad95d6"]}}