biostudies-literatureUnknown69(24)Ma CNIBIB NIH HHSNCI NIH HHSNational Institutes of Health<i>Objective.</i>We previously developed a FLASH planning framework for streamlined pin-ridge-filter (pin-RF) design, demonstrating its feasibility for single-energy proton FLASH planning. In this study, we refined the pin-RF design for easy assembly using reusable modules, focusing on its application in liver stereotactic ablative body radiotherapy (SABR).<i>Approach.</i>This framework generates an intermediate intensity-modulated proton therapy (IMPT) plan and translates it into step widths and thicknesses of pin-RFs for a single-energy FLASH plan. Parameters like energy spacing, monitor unit limit, and spot quantity were adjusted during IMPT planning, resulting in pin-RFs assembled using predefined modules with widths from 1 to 6 mm, each with a water-equivalent-thickness of 5 mm. This Physics in medicine and biologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC11653111biostudies-literatureFeasibility study of modularized pin ridge filter implementation in proton FLASH planning for liver stereotactic ablative body radiotherapy.PMC11653111R01CA272991U54 CA274513R56EB033332U54CA274513R01EB032680R01 CA272991R01 EB032680R56 EB033332Yang XPatel PSetianegara JMa CGao YYu DWang YZhou JfalseFeasibility study of modularized pin ridge filter implementation in proton FLASH planning for liver stereotactic ablative body radiotherapy.<i>Objective.</i>We previously developed a FLASH planning framework for streamlined pin-ridge-filter (pin-RF) design, demonstrating its feasibility for single-energy proton FLASH planning. In this study, we refined the pin-RF design for easy assembly using reusable modules, focusing on its application in liver stereotactic ablative body radiotherapy (SABR).<i>Approach.</i>This framework generates an intermediate intensity-modulated proton therapy (IMPT) plan and translates it into step widths and thicknesses of pin-RFs for a single-energy FLASH plan. Parameters like energy spacing, monitor unit limit, and spot quantity were adjusted during IMPT planning, resulting in pin-RFs assembled using predefined modules with widths from 1 to 6 mm, each with a water-equivalent-thickness of 5 mm. This 2024-01-01T00:00:00Z2024 Dec2026-06-06T14:35:14.491Z2026-05-31T03:10:00.69ZS-EPMC116531113957128310.1088/1361-6560/ad95d6