{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roberts AL"],"funding":["NIMH NIH HHS","NCI NIH HHS","National Institutes of Health"],"pagination":["672-680"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11653203"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["123"],"pubmed_abstract":["Posttraumatic stress disorder (PTSD) is associated with mortality and increased risk of diseases of aging, but underlying mechanisms remain unclear. We examine associations of PTSD with one potential pathway, accelerated epigenetic aging. In a longitudinal cohort of trauma-exposed middle-aged women (n = 831, n observations = 1,516), we examined cross-sectional and longitudinal associations between PTSD, with and without comorbid depression, and epigenetic aging measured by six clocks at two time points approximately 13.5 years apart: Hannum, Horvath, PhenoAge, GrimAge, DunedinPoAM, and DunedinPACE. We further examined associations of 3 well-established predictors of aging and mortality also linked with PTSD, namely, body mass index (BMI), diet quality, and physical activity, with epigeneti"],"journal":["Brain, behavior, and immunity"],"pubmed_title":["No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study."],"pmcid":["PMC11653203"],"funding_grant_id":["R01 MH101269","R01 CA67262","U01 CA176726","R01 CA067262","U01 CA067262"],"pubmed_authors":["Roberts AL","Ratanatharathorn A","Chibnik L","Zhu Y","Jha S","Kubzansky LD","Kang JH","Koenen KC","Wolf EJ"],"additional_accession":[]},"is_claimable":false,"name":"No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study.","description":"Posttraumatic stress disorder (PTSD) is associated with mortality and increased risk of diseases of aging, but underlying mechanisms remain unclear. We examine associations of PTSD with one potential pathway, accelerated epigenetic aging. In a longitudinal cohort of trauma-exposed middle-aged women (n = 831, n observations = 1,516), we examined cross-sectional and longitudinal associations between PTSD, with and without comorbid depression, and epigenetic aging measured by six clocks at two time points approximately 13.5 years apart: Hannum, Horvath, PhenoAge, GrimAge, DunedinPoAM, and DunedinPACE. We further examined associations of 3 well-established predictors of aging and mortality also linked with PTSD, namely, body mass index (BMI), diet quality, and physical activity, with epigeneti","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-14T03:12:36.84Z","creation":"2026-06-14T03:08:25.596Z"},"accession":"S-EPMC11653203","cross_references":{"pubmed":["39424013"],"doi":["10.1016/j.bbi.2024.10.003"]}}