{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang D"],"funding":["Research and Development Program, West China Hospital of Stomatology, Sichuan University","National Natural Science Foundation of China","Chinese Academy of Medical Sciences Initiative for Innovative Medicine"],"pagination":["1227-1237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11653335"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["103(12)"],"pubmed_abstract":["Oral leukoplakia (OLK) is the most representative oral potentially malignant disorder, with a high risk of malignant transformation and unclear mechanisms of occurrence. Recently, photodynamic therapy (PDT) has exhibited great potential in the treatment of OLK. However, the efficacy of PDT is difficult to predict and varies from person to person. Ferroptosis-related pathways are upregulated in many cancers, and ferroptosis induction is considered to be a potential synergistic strategy for various antitumor therapies, but its role in OLK treatment remains unclear. This study aimed to determine whether ferroptosis induction can enhance the efficacy of PDT in OLK treatment. Our study revealed that solute carrier family 7 member 11 (SLC7A11), a component of a crucial amino acid transporter and"],"journal":["Journal of dental research"],"pubmed_title":["Ferroptosis Induction Enhances Photodynamic Therapy Efficacy for OLK."],"pmcid":["PMC11653335"],"funding_grant_id":["LCYJ2019-11","82071125","82273320","82072999","82370965","2019-I2M-5-004","82270986"],"pubmed_authors":["Liu J","Chen Q","Dan H","Li J","Feng X","Zeng X","Yang D","Wang Y","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Ferroptosis Induction Enhances Photodynamic Therapy Efficacy for OLK.","description":"Oral leukoplakia (OLK) is the most representative oral potentially malignant disorder, with a high risk of malignant transformation and unclear mechanisms of occurrence. Recently, photodynamic therapy (PDT) has exhibited great potential in the treatment of OLK. However, the efficacy of PDT is difficult to predict and varies from person to person. Ferroptosis-related pathways are upregulated in many cancers, and ferroptosis induction is considered to be a potential synergistic strategy for various antitumor therapies, but its role in OLK treatment remains unclear. This study aimed to determine whether ferroptosis induction can enhance the efficacy of PDT in OLK treatment. Our study revealed that solute carrier family 7 member 11 (SLC7A11), a component of a crucial amino acid transporter and","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-05T07:33:04.021Z","creation":"2026-05-14T03:12:04.193Z"},"accession":"S-EPMC11653335","cross_references":{"pubmed":["39394822"],"doi":["10.1177/00220345241280257"]}}