biostudies-literatureUnknown24(1)Shacho E<h4>Background</h4>Healthcare-associated infections (HCAIs) are a common challenge faced in healthcare facilities, particularly in low- and middle-income countries (LMICs). Evaluating the level of knowledge, attitude, and practice (KAP) among healthcare personnel regarding HCAI prevention and identifying the relevant factors is important for handling and controlling these infections. Therefore, this study aimed to assess the direct and indirect effects of knowledge, attitude, and practices of healthcare workers (HCW) towards HCAIs prevention in Jimma University Medical Center (JUMC).<h4>Method</h4>An institutional cross-sectional study was conducted from March to April 2022. A total of 262 was sampled from 1354 health professionals working in JUMC using the population proportion stratifiedBMC health services research1611https://www.ebi.ac.uk/biostudies/studies/S-EPMC11653541biostudies-literatureKnowledge, attitude, and practice of healthcare workers towards healthcare- associated infections in Jimma University Medical Center, southwestern Ethiopia: using structural equation model.PMC11653541Shacho EYilma DAmbelu AfalseKnowledge, attitude, and practice of healthcare workers towards healthcare- associated infections in Jimma University Medical Center, southwestern Ethiopia: using structural equation model.<h4>Background</h4>Healthcare-associated infections (HCAIs) are a common challenge faced in healthcare facilities, particularly in low- and middle-income countries (LMICs). Evaluating the level of knowledge, attitude, and practice (KAP) among healthcare personnel regarding HCAI prevention and identifying the relevant factors is important for handling and controlling these infections. Therefore, this study aimed to assess the direct and indirect effects of knowledge, attitude, and practices of healthcare workers (HCW) towards HCAIs prevention in Jimma University Medical Center (JUMC).<h4>Method</h4>An institutional cross-sectional study was conducted from March to April 2022. A total of 262 was sampled from 1354 health professionals working in JUMC using the population proportion stratified2024-01-01T00:00:00Z2024 Dec2025-04-27T00:28:35.415Z2025-04-06T17:51:17.538ZS-EPMC116535413969649010.1186/s12913-024-12094-6