{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ouyang F"],"funding":["Scientific Research Project of Yun'nan Provincial Department of Education","Key Guidance Projects for University of South China","Research Start-up Fund of the Second Affiliated Hospital of Hengyang Medical College of University of South China","Hunan Provincial Postdoctoral Science Foundation","Scientific Research Project of Hunan Provincial Health Commission of China","Foundation of Hunan Provincial Key Laboratory","Hengyang Science and Technology Plan Special Fund","Scientific Research Project of Hunan Provincial Department of Education","National Natural Science Foundation of China","Clinical Research 4310 Program of the First Affiliated Hospital of University of South China"],"pagination":["e2406026"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11653682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(47)"],"pubmed_abstract":["Aloe emodin is an anthraquinone of traditional Chinese medicine monomer, which plays a protective action in cardiovascular diseases. However, the regulatory mechanisms of aloe emodin in the protection of radiation-induced heart damage (RIHD) are unclear. As a novel post-translational modification, lactylation is considered as a critical mediator in inflammatory cascade and cardiac injury. Here, using a cross of differential omics and 4D label-free lactylation omics, protein disulfide-isomerase (P4HB) is identified as a novel target for lactylation, and aloe emodin inhibits the binding of lactate to the K311 site of P4HB. Aloe emodin stabilizes kynurenine metabolism through inhibition of aspartate aminotransferase (GOT2) accumulation on damaged mitochondria. Mechanistically, aloe emodin inh"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption."],"pmcid":["PMC11653682"],"funding_grant_id":["20224310NHYCG03","2020SK4010","nk2020106","21B0407","82303246","2019jh426001","2023JJ41066","2023JJ40573","2023TP1014","2024JJ9383","2023JJ40578","2023JJ40579","82304076","202203013975","82070426","2023JJ60048","2022JJ40386","2022J1522","S2022JJSSLH0406","2021B02"],"pubmed_authors":["Gao A","Zhou L","Fang J","Wang H","Liu X","Li Y","Xie G","Luo Q","Hou K","Tan X","Ouyang F","Zhang X","Zeng J","Chen S","Zeng G","Zhou H"],"additional_accession":[]},"is_claimable":false,"name":"Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.","description":"Aloe emodin is an anthraquinone of traditional Chinese medicine monomer, which plays a protective action in cardiovascular diseases. However, the regulatory mechanisms of aloe emodin in the protection of radiation-induced heart damage (RIHD) are unclear. As a novel post-translational modification, lactylation is considered as a critical mediator in inflammatory cascade and cardiac injury. Here, using a cross of differential omics and 4D label-free lactylation omics, protein disulfide-isomerase (P4HB) is identified as a novel target for lactylation, and aloe emodin inhibits the binding of lactate to the K311 site of P4HB. Aloe emodin stabilizes kynurenine metabolism through inhibition of aspartate aminotransferase (GOT2) accumulation on damaged mitochondria. Mechanistically, aloe emodin inh","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-01T17:38:58.519Z","creation":"2025-04-06T01:55:18.361Z"},"accession":"S-EPMC11653682","cross_references":{"pubmed":["39494721"],"doi":["10.1002/advs.202406026"]}}