{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Geleta D"],"pubmed_abstract":["<h4>Background</h4>Klebsiella bacterial strains harboring Extended-Spectrum Beta-Lactamase (ESBL) enzymes are the primary culprits behind neonatal sepsis globally. These strains significantly impact clinical outcomes due to their multi-drug resistance patterns in local healthcare settings. In response to this spiraling threat, we studied the prevalence and clinical implications of ESBL-encoding genes in neonates hospitalized with confirmed sepsis.<h4>Methods</h4>A correlational study was conducted on 51 neonates diagnosed with sepsis caused by ESBL-positive Klebsiella pneumoniae at Jimma Medical Center spanning from May 2022 to July 2023. Antimicrobial resistance profiles of the bacterial isolates were determined using the Kirby-Bauer diffusion test, while multiplex polymerase chain reacti"],"journal":["BMC infectious diseases"],"pagination":["1442"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11653740"],"repository":["biostudies-literature"],"pubmed_title":["Molecular and clinical insights into extended-spectrum β-lactamase genes of Klebsiella pneumoniae isolated from neonatal sepsis in Ethiopia."],"pmcid":["PMC11653740"],"pubmed_authors":["Mihret A","Workneh N","Geleta D","Abebe G","Abdissa A","Cataldo RJ","Negash AA","Tilahun T","Beyene G"],"additional_accession":[]},"is_claimable":false,"name":"Molecular and clinical insights into extended-spectrum β-lactamase genes of Klebsiella pneumoniae isolated from neonatal sepsis in Ethiopia.","description":"<h4>Background</h4>Klebsiella bacterial strains harboring Extended-Spectrum Beta-Lactamase (ESBL) enzymes are the primary culprits behind neonatal sepsis globally. These strains significantly impact clinical outcomes due to their multi-drug resistance patterns in local healthcare settings. In response to this spiraling threat, we studied the prevalence and clinical implications of ESBL-encoding genes in neonates hospitalized with confirmed sepsis.<h4>Methods</h4>A correlational study was conducted on 51 neonates diagnosed with sepsis caused by ESBL-positive Klebsiella pneumoniae at Jimma Medical Center spanning from May 2022 to July 2023. Antimicrobial resistance profiles of the bacterial isolates were determined using the Kirby-Bauer diffusion test, while multiplex polymerase chain reacti","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-18T14:22:28.006Z","creation":"2025-04-04T21:45:28.691Z"},"accession":"S-EPMC11653740","cross_references":{"pubmed":["39695444"],"doi":["10.1186/s12879-024-10344-w"]}}