biostudies-literatureUnknown57(1)Chen Y<h4>Background</h4>Accumulating evidence has demonstrated that the long non-coding RNA (lncRNA) lymphocytic leukaemia deletion gene 1 (DLEU1) is abnormally overexpressed in many cancer types, including cervical cancer (CC). However, the potential clinical significance of DLEU1 in serum exosomes of patients with CC remains unclear.<h4>Methods</h4>The expression of serum exosomal DLEU1 was detected by quantitative real-time polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was plotted to evaluate the clinical diagnostic efficacy of DLEU1. The Kaplan-Meier survival curve and Cox proportional hazards model were used to assess the effect of DLEU1 on postoperative recurrence, metastasis and prognosis among patients with CC.<h4>Results</h4>Our research showed thAnnals of medicine2442537https://www.ebi.ac.uk/biostudies/studies/S-EPMC11654034biostudies-literatureThe expression and clinical significance of serum exosomal-long non-coding RNA DLEU1 in patients with cervical cancer.PMC11654034Zhao WXia QChen YCui FWu XfalseThe expression and clinical significance of serum exosomal-long non-coding RNA DLEU1 in patients with cervical cancer.<h4>Background</h4>Accumulating evidence has demonstrated that the long non-coding RNA (lncRNA) lymphocytic leukaemia deletion gene 1 (DLEU1) is abnormally overexpressed in many cancer types, including cervical cancer (CC). However, the potential clinical significance of DLEU1 in serum exosomes of patients with CC remains unclear.<h4>Methods</h4>The expression of serum exosomal DLEU1 was detected by quantitative real-time polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was plotted to evaluate the clinical diagnostic efficacy of DLEU1. The Kaplan-Meier survival curve and Cox proportional hazards model were used to assess the effect of DLEU1 on postoperative recurrence, metastasis and prognosis among patients with CC.<h4>Results</h4>Our research showed th2025-01-01T00:00:00Z2025 Dec2025-04-26T17:00:16.518Z2025-04-06T15:24:39.817ZS-EPMC116540343968798210.1080/07853890.2024.2442537