biostudies-literatureHendy DANational Institute of Allergy and Infectious DiseasesNIAID NIH HHS4687-4697https://www.ebi.ac.uk/biostudies/studies/S-EPMC11654055biostudies-literatureUnknown20(9)Current seasonal influenza vaccines are limited in that they need to be reformulated every year in order to account for the constant mutation of the virus. Hemagglutinin (HA) immunogens have been developed using a computationally optimized broadly reactive antigen (COBRA) methodology, which are able to elicit an antibody response that neutralizes antigenically distinct influenza strains; however, subunit proteins are not immunogenic enough on their own to generate a substantial immune response. Due to this, different delivery strategies and adjuvants can be used to improve immunogenicity. Recently, we reported a new coordination polymer composed of the dipeptide carnosine and zinc (ZnCar) that is able to deliver protein antigens along with CpG to generate a potent immune response. In the pMolecular pharmaceuticsZinc Carnosine Metal-Organic Coordination Polymer as a Potent Broadly Active Influenza Vaccine Platform with In Vitro Shelf-Stability.PMC11654055NIH R01AI14749775N93019C00052R01 AI147497Hendy DAAinslie KMMousa JJBachelder EMLifshits LMBatty CJCarlock MARoss TMfalseZinc Carnosine Metal-Organic Coordination Polymer as a Potent Broadly Active Influenza Vaccine Platform with In Vitro Shelf-Stability.Current seasonal influenza vaccines are limited in that they need to be reformulated every year in order to account for the constant mutation of the virus. Hemagglutinin (HA) immunogens have been developed using a computationally optimized broadly reactive antigen (COBRA) methodology, which are able to elicit an antibody response that neutralizes antigenically distinct influenza strains; however, subunit proteins are not immunogenic enough on their own to generate a substantial immune response. Due to this, different delivery strategies and adjuvants can be used to improve immunogenicity. Recently, we reported a new coordination polymer composed of the dipeptide carnosine and zinc (ZnCar) that is able to deliver protein antigens along with CpG to generate a potent immune response. In the p2023-01-01T00:00:00Z2023 Sep2025-04-27T00:30:07.267Z2025-04-06T17:50:50.451ZS-EPMC116540553760331010.1021/acs.molpharmaceut.3c00424