{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(51)"],"submitter":["Lee U"],"pubmed_abstract":["Previous evolutionary models of duplicate gene evolution have overlooked the pivotal role of genome architecture. Here, we show that proximity-based regulatory recruitment by distally duplicated genes is an efficient mechanism for modulating tissue-specific production of preexisting proteins. By leveraging genomic asymmetries, we performed a coexpression analysis on <i>Drosophila melanogaster</i> tissue data to show the generality of enhancer capture-divergence (ECD) as a significant evolutionary driver of asymmetric, distally duplicated genes. We use the recently evolved gene <i>HP6</i>/<i>Umbrea</i> as an example of the ECD process. By assaying genome-wide chromosomal conformations in multiple <i>Drosophila</i> species, we show that <i>HP6/Umbrea</i> was inserted near a preexisting, long"],"journal":["Science advances"],"pagination":["eadn6625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11654672"],"repository":["biostudies-literature"],"pubmed_title":["The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence."],"pmcid":["PMC11654672"],"pubmed_authors":["Arsala D","Li C","Sobreira DR","Zhou Q","Chen J","Andolfatto P","Long M","Xia S","Zhang L","Ali M","Eres I","Svetec N","Langer CB","Zhao L","Reilly P","Guzzetta A","Emerson JJ","Sosa D","Lee U"],"additional_accession":[]},"is_claimable":false,"name":"The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence.","description":"Previous evolutionary models of duplicate gene evolution have overlooked the pivotal role of genome architecture. Here, we show that proximity-based regulatory recruitment by distally duplicated genes is an efficient mechanism for modulating tissue-specific production of preexisting proteins. By leveraging genomic asymmetries, we performed a coexpression analysis on <i>Drosophila melanogaster</i> tissue data to show the generality of enhancer capture-divergence (ECD) as a significant evolutionary driver of asymmetric, distally duplicated genes. We use the recently evolved gene <i>HP6</i>/<i>Umbrea</i> as an example of the ECD process. By assaying genome-wide chromosomal conformations in multiple <i>Drosophila</i> species, we show that <i>HP6/Umbrea</i> was inserted near a preexisting, long","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-22T10:40:39.786Z","creation":"2025-04-05T23:43:16.969Z"},"accession":"S-EPMC11654672","cross_references":{"pubmed":["39693425"],"doi":["10.1126/sciadv.adn6625"]}}