{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Seremet T"],"funding":["Swiss National Science Foundation"],"pagination":["10688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11655867"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with"],"journal":["Nature communications"],"pubmed_title":["Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases."],"pmcid":["PMC11655867"],"funding_grant_id":["310030_204835","310030B_182834","182834","4078P0_198470","310030","204835"],"pubmed_authors":["Schlapbach C","Bogiatzi S","Girardin A","Hohl D","Guenova E","Eyerich K","Vernez M","Eyerich S","Yatim A","Garzorz-Stark N","Gottardo R","Leuenberger M","Saidoune F","Paul C","Gilliet M","Jenelten R","Messina F","Seremet T","Wuthrich H","Conrad C","Minisini F","Di Domizio J"],"additional_accession":[]},"is_claimable":false,"name":"Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases.","description":"Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T01:51:57.912Z","creation":"2025-04-04T01:51:57.912Z"},"accession":"S-EPMC11655867","cross_references":{"pubmed":["39695162"],"doi":["10.1038/s41467-024-54559-6"]}}