biostudies-literatureSeremet TSwiss National Science Foundation10688https://www.ebi.ac.uk/biostudies/studies/S-EPMC11655867biostudies-literatureUnknown15(1)Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules withNature communicationsImmune modules to guide diagnosis and personalized treatment of inflammatory skin diseases.PMC11655867310030_204835310030B_1828341828344078P0_198470310030204835Schlapbach CBogiatzi SGirardin AHohl DGuenova EEyerich KVernez MEyerich SYatim AGarzorz-Stark NGottardo RLeuenberger MSaidoune FPaul CGilliet MJenelten RMessina FSeremet TWuthrich HConrad CMinisini FDi Domizio JfalseImmune modules to guide diagnosis and personalized treatment of inflammatory skin diseases.Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with2024-01-01T00:00:00Z2024 Dec2025-04-04T01:51:57.912Z2025-04-04T01:51:57.912ZS-EPMC116558673969516210.1038/s41467-024-54559-6