{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu M"],"funding":["Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation)","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11655871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Angioimmunoblastic T-cell lymphoma (AITL) is a kind of aggressive T-cell lymphoma with significant enrichment of non-malignant tumor microenvironment (TME) cells. However, the complexity of TME in AITL progression is poorly understood. We performed single-cell RNA-Seq (scRNA-seq) and imaging mass cytometry (IMC) analysis to compare the cellular composition and spatial architecture between relapsed/refractory AITL (RR-AITL) and newly diagnosed AITL (ND-AITL). Our results showed that the malignant T follicular helper (Tfh) cells showed significantly increased proliferation driven by transcriptional activation of YY1 in RR-AITL, which is markedly associated with the poor prognosis of AITL patients. The CD8<sup>+</sup> T cell proportion and cytotoxicity decreased in RR-AITL TME, resulting from"],"journal":["Blood cancer journal"],"pubmed_title":["Single-cell transcriptomic and spatial analysis reveal the immunosuppressive microenvironment in relapsed/refractory angioimmunoblastic T-cell lymphoma."],"pmcid":["PMC11655871"],"funding_grant_id":["91959113","BK20210530","82370193","32200590","BK20211376","82170185","82372897","81972358"],"pubmed_authors":["Cao L","Yu L","Wu L","Lu X","Wang C","Ren Y","Hu X","Liu Q","Shi W","Zhang L","Lin Z","Huang R","Zhang R","Shi Y","Leng J","Jin H","Wang Q","Fan L","Wu R","Wu W","Huang B","Chen R","Li J","Lu C","Xia P","Zhou W","Li K","Li N","Zhu M","Zhong S","Yao D","Cai Y","Lv S"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomic and spatial analysis reveal the immunosuppressive microenvironment in relapsed/refractory angioimmunoblastic T-cell lymphoma.","description":"Angioimmunoblastic T-cell lymphoma (AITL) is a kind of aggressive T-cell lymphoma with significant enrichment of non-malignant tumor microenvironment (TME) cells. However, the complexity of TME in AITL progression is poorly understood. We performed single-cell RNA-Seq (scRNA-seq) and imaging mass cytometry (IMC) analysis to compare the cellular composition and spatial architecture between relapsed/refractory AITL (RR-AITL) and newly diagnosed AITL (ND-AITL). Our results showed that the malignant T follicular helper (Tfh) cells showed significantly increased proliferation driven by transcriptional activation of YY1 in RR-AITL, which is markedly associated with the poor prognosis of AITL patients. The CD8<sup>+</sup> T cell proportion and cytotoxicity decreased in RR-AITL TME, resulting from","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T21:45:33.252Z","creation":"2025-04-04T21:45:33.252Z"},"accession":"S-EPMC11655871","cross_references":{"pubmed":["39695118"],"doi":["10.1038/s41408-024-01199-0"]}}