{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["63(52)"],"submitter":["Caporaletti F"],"funding":["Fonds De La Recherche Scientifique - FNRS"],"pubmed_abstract":["Using fluorinated mono-alcohols, in particular hexafluoro-isopropanol (HFIP), as a solvent can enhance chemical reaction rates in a spectacular manner. Previous work has shown evidence that this enhancement is related to the hydrogen-bond structure of these liquids. Here, we investigate the hydrogen-bond dynamics of HFIP and compare it to that of its non-fluorinated analog, isopropanol. Ultrafast infrared spectroscopy experiments show that the dynamics of individual hydrogen-bonds is about twice as slow in HFIP as in isopropanol. Surprisingly, from dielectric spectroscopy we find the opposite behavior for the dynamics of hydrogen-bonded clusters: collective rearrangements are 3 times faster in HFIP than in isopropanol. This difference indicates that the hydrogen-bonded clusters in HFIP are"],"journal":["Angewandte Chemie (International ed. in English)"],"pagination":["e202416091"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656151"],"repository":["biostudies-literature"],"pubmed_title":["Fast Collective Hydrogen-Bond Dynamics in Hexafluoroisopropanol Related to its Chemical Activity."],"pmcid":["PMC11656151"],"pubmed_authors":["Hunger J","Caporaletti F","Gunkel L","Woutersen S","Fernandez-Ibanez MA"],"additional_accession":[]},"is_claimable":false,"name":"Fast Collective Hydrogen-Bond Dynamics in Hexafluoroisopropanol Related to its Chemical Activity.","description":"Using fluorinated mono-alcohols, in particular hexafluoro-isopropanol (HFIP), as a solvent can enhance chemical reaction rates in a spectacular manner. Previous work has shown evidence that this enhancement is related to the hydrogen-bond structure of these liquids. Here, we investigate the hydrogen-bond dynamics of HFIP and compare it to that of its non-fluorinated analog, isopropanol. Ultrafast infrared spectroscopy experiments show that the dynamics of individual hydrogen-bonds is about twice as slow in HFIP as in isopropanol. Surprisingly, from dielectric spectroscopy we find the opposite behavior for the dynamics of hydrogen-bonded clusters: collective rearrangements are 3 times faster in HFIP than in isopropanol. This difference indicates that the hydrogen-bonded clusters in HFIP are","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T01:52:01.554Z","creation":"2025-04-04T01:52:01.554Z"},"accession":"S-EPMC11656151","cross_references":{"pubmed":["39388385"],"doi":["10.1002/anie.202416091"]}}