biostudies-literatureFlood RJScience Foundation IrelandUniversity of Galway1686-1690https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656731biostudies-literatureUnknown13(12)Engineered protein cages are of great interest considering their diverse applications in delivery and catalysis. Here, we describe macrocycle-triggered icosahedral cage assembly of a designed β-propeller. Cage assembly was evidenced by small-angle X-ray scattering and X-ray crystallography.ACS macro lettersA Macrocycle-Mediated Protein Cage.PMC1165673112/RC/2275_P2Thureau ACrowley PBFlood RJfalseA Macrocycle-Mediated Protein Cage.Engineered protein cages are of great interest considering their diverse applications in delivery and catalysis. Here, we describe macrocycle-triggered icosahedral cage assembly of a designed β-propeller. Cage assembly was evidenced by small-angle X-ray scattering and X-ray crystallography.2024-01-01T00:00:00Z2024 Dec2026-06-03T00:47:37.237Z2025-04-04T00:38:33.078ZS-EPMC116567313959226010.1021/acsmacrolett.4c00656