{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ellepola K"],"funding":["HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)"],"pagination":["e0030824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656736"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(12)"],"pubmed_abstract":["Our recent studies have shown that deficiency of MecA in <i>Streptococcus mutans</i> significantly affects cell division, growth, and biofilm formation. In this study, an <i>in vitro</i> mixed-species model, proteomics, and affinity pull-down assays were used to further characterize the MecA-mediated regulation in <i>S. mutans</i>. The results showed that compared with the wild type, UA159, the <i>mecA</i> mutant significantly reduced its production of glucans and weakened its ability to facilitate mixed-species biofilm formation. Relative to the wild type, the <i>mecA</i> mutant also displayed unique characteristics, including colony morphology, growth rate, and biofilm formation that did not fully resemble any of the <i>clpP, clpX, clpE, clpCE,</i> and <i>clpC</i> individual or combinati"],"journal":["mSphere"],"pubmed_title":["MecA in &lt;i&gt;Streptococcus mutans&lt;/i&gt; is a multi-functional protein."],"pmcid":["PMC11656736"],"funding_grant_id":["DE019452"],"pubmed_authors":["Lemos JA","Ellepola K","Kajfasz JK","Zhang H","Shields RC","Wen ZT","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"MecA in &lt;i&gt;Streptococcus mutans&lt;/i&gt; is a multi-functional protein.","description":"Our recent studies have shown that deficiency of MecA in <i>Streptococcus mutans</i> significantly affects cell division, growth, and biofilm formation. In this study, an <i>in vitro</i> mixed-species model, proteomics, and affinity pull-down assays were used to further characterize the MecA-mediated regulation in <i>S. mutans</i>. The results showed that compared with the wild type, UA159, the <i>mecA</i> mutant significantly reduced its production of glucans and weakened its ability to facilitate mixed-species biofilm formation. Relative to the wild type, the <i>mecA</i> mutant also displayed unique characteristics, including colony morphology, growth rate, and biofilm formation that did not fully resemble any of the <i>clpP, clpX, clpE, clpCE,</i> and <i>clpC</i> individual or combinati","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T01:46:07.912Z","creation":"2025-04-04T01:46:07.912Z"},"accession":"S-EPMC11656736","cross_references":{"pubmed":["39530674"],"doi":["10.1128/msphere.00308-24"]}}