{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lan H"],"funding":["the Intramural Research Program of Liyuan Hospital","Hubei Provincial Natural Science Foundation Joint Fund for Innovation and Development Project","National Natural Science Foundation of China"],"pagination":["775"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656764"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB). The L-AB effectively inherited \"eat me\" signaling molecules on the surface of the AB, thereby facilitating their targeted uptake by macrophages in both in vitro and in vivo settings. The administration of L-AB for the delivery of dexamethasone effectively augmented the"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment."],"pmcid":["PMC11656764"],"funding_grant_id":["No. 2023LYYYGZRP0002","No.82373816","No. 2024AFD347"],"pubmed_authors":["Li X","Kong L","Fu D","Guo Y","Zhang Z","Tian T","Hu Q","Xie Q","Wang Y","Lan H","Yang C","Zhou Z"],"additional_accession":[]},"is_claimable":false,"name":"Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.","description":"Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB). The L-AB effectively inherited \"eat me\" signaling molecules on the surface of the AB, thereby facilitating their targeted uptake by macrophages in both in vitro and in vivo settings. The administration of L-AB for the delivery of dexamethasone effectively augmented the","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-22T10:43:17.597Z","creation":"2025-04-05T23:43:10.293Z"},"accession":"S-EPMC11656764","cross_references":{"pubmed":["39695736"],"doi":["10.1186/s12951-024-03058-3"]}}