biostudies-literatureLan Hthe Intramural Research Program of Liyuan HospitalHubei Provincial Natural Science Foundation Joint Fund for Innovation and Development ProjectNational Natural Science Foundation of China775https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656764biostudies-literatureUnknown22(1)Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB). The L-AB effectively inherited "eat me" signaling molecules on the surface of the AB, thereby facilitating their targeted uptake by macrophages in both in vitro and in vivo settings. The administration of L-AB for the delivery of dexamethasone effectively augmented theJournal of nanobiotechnologyApoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.PMC11656764No. 2023LYYYGZRP0002No.82373816No. 2024AFD347Li XKong LFu DGuo YZhang ZTian THu QXie QWang YLan HYang CZhou ZfalseApoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB). The L-AB effectively inherited "eat me" signaling molecules on the surface of the AB, thereby facilitating their targeted uptake by macrophages in both in vitro and in vivo settings. The administration of L-AB for the delivery of dexamethasone effectively augmented the2024-01-01T00:00:00Z2024 Dec2025-04-22T10:43:17.597Z2025-04-05T23:43:10.293ZS-EPMC116567643969573610.1186/s12951-024-03058-3