{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Werner Lass S"],"funding":["HHS | NIH | NIH Office of the Director","Shurl and Kay Curci Foundation (SKCF)","HHS | NIH | National Institute of General Medical Sciences","ODCDC CDC HHS","NSF | National Science Foundation Graduate Research Fellowship Program","NSF | National Science Foundation Graduate Research Fellowship Program (GRFP)","Shurl and Kay Curci Foundation","HHS | NIH | National Institute of General Medical Sciences (NIGMS)"],"pagination":["e0072724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656791"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(12)"],"pubmed_abstract":["Bacterial cells secrete extracellular vesicles (EVs), the function of which is a matter of intense investigation. Here, we show that the EVs secreted by the human pathogen <i>Streptococcus pneumoniae</i> (pneumococcus) are associated with bacterial DNA on their surface and can deliver this DNA to the transformation machinery of competent cells. These findings suggest that EVs contribute to gene transfer in Gram-positive bacteria and, in doing so, may promote the spread of drug resistance genes in the population.IMPORTANCEThis work extends our understanding of horizontal gene transfer and the roles of extracellular vesicles in pneumococcus. This bacterium serves as the model for transformation, a process by which bacteria can take up naked DNA from the environment. Here, we show that extrac"],"journal":["mSphere"],"pubmed_title":["Pneumococcal extracellular vesicles mediate horizontal gene transfer via the transformation machinery."],"pmcid":["PMC11656791"],"funding_grant_id":["S10 OD025009","5T32GM133353-04"],"pubmed_authors":["Arun A","Rosch JW","Conway JF","Smith BE","Campbell P","Hiller NL","Prentice JA","Yerneni SS","Bridges AA","Camphire S","Eutsey RA","Werner Lass S"],"additional_accession":[]},"is_claimable":false,"name":"Pneumococcal extracellular vesicles mediate horizontal gene transfer via the transformation machinery.","description":"Bacterial cells secrete extracellular vesicles (EVs), the function of which is a matter of intense investigation. Here, we show that the EVs secreted by the human pathogen <i>Streptococcus pneumoniae</i> (pneumococcus) are associated with bacterial DNA on their surface and can deliver this DNA to the transformation machinery of competent cells. These findings suggest that EVs contribute to gene transfer in Gram-positive bacteria and, in doing so, may promote the spread of drug resistance genes in the population.IMPORTANCEThis work extends our understanding of horizontal gene transfer and the roles of extracellular vesicles in pneumococcus. This bacterium serves as the model for transformation, a process by which bacteria can take up naked DNA from the environment. Here, we show that extrac","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T01:08:48.392Z","creation":"2025-04-04T01:08:48.392Z"},"accession":"S-EPMC11656791","cross_references":{"pubmed":["39503503"],"doi":["10.1128/msphere.00727-24"]}}