biostudies-literatureUnknown9(12)Tang JScientific Research Start-up Funding for Advanced Talents of Linyi University (Z6124035); National Natural Science Foundation of China (32402867)Porcine epidemic diarrhea virus (PEDV), the major causative pathogen of porcine epidemic diarrhea, poses a severe threat to the swine industry, particularly affecting neonatal piglets. Maternal milk-derived IgA antibody is crucial for protecting piglets from PEDV infection. Despite the effectiveness of current intramuscularly administered PEDV vaccines in inducing strong systemic immune responses, their ability to generate high levels of maternal milk IgA is limited. This study explores the potential of Astragalus polysaccharide (APS) to enhance PEDV vaccine efficacy, specifically focusing on maternal milk IgA levels. We first evaluated anti-PEDV antibody levels in the blood and colostrum of sows vaccinated with PEDV or subjected to feedback feeding. Our results indicated that while vaccinmSpheree0077724https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656797biostudies-literatureAstragalus polysaccharide enhances maternal mucosal immunity against PEDV.PMC11656797Tang JLi JWang SfalseAstragalus polysaccharide enhances maternal mucosal immunity against PEDV.Porcine epidemic diarrhea virus (PEDV), the major causative pathogen of porcine epidemic diarrhea, poses a severe threat to the swine industry, particularly affecting neonatal piglets. Maternal milk-derived IgA antibody is crucial for protecting piglets from PEDV infection. Despite the effectiveness of current intramuscularly administered PEDV vaccines in inducing strong systemic immune responses, their ability to generate high levels of maternal milk IgA is limited. This study explores the potential of Astragalus polysaccharide (APS) to enhance PEDV vaccine efficacy, specifically focusing on maternal milk IgA levels. We first evaluated anti-PEDV antibody levels in the blood and colostrum of sows vaccinated with PEDV or subjected to feedback feeding. Our results indicated that while vaccin2024-01-01T00:00:00Z2024 Dec2025-04-18T14:39:28.342Z2025-04-07T00:54:14.255ZS-EPMC116567973954072510.1128/msphere.00777-24