{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu W"],"funding":["the National Natural Science Foundation of China"],"pagination":["95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656970"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>H1-antihistamines are widely used to treat symptoms depending on histamine release in a variety of conditions. However, neurological adverse events have been reported in post-marketing surveillance studies and there are limited literatures comparing the neurological disorders associated with newer-generation H1-antihistamines from real-world datasets.<h4>Aims</h4>We performed a comparative analysis of nervous system disorders and several newer-generation H1-antihistamines including: cetirizine, loratadine, levocetirizine, desloratadine and fexofenadine.<h4>Methods</h4>Disproportionality analysis was used to identify the suspected drug neurological adverse events associated with H1-antihistamines of interest via the Food and Drug Administration Adverse Event Reporting Sys"],"journal":["BMC pharmacology & toxicology"],"pubmed_title":["Data mining in FAERS: association of newer-generation H1-antihistamines with nervous system disorders."],"pmcid":["PMC11656970"],"funding_grant_id":["No. 82071686"],"pubmed_authors":["Li H","Hu W","Zeng L","Chen L","Gan J","Zhang L","Feng C"],"additional_accession":[]},"is_claimable":false,"name":"Data mining in FAERS: association of newer-generation H1-antihistamines with nervous system disorders.","description":"<h4>Background</h4>H1-antihistamines are widely used to treat symptoms depending on histamine release in a variety of conditions. However, neurological adverse events have been reported in post-marketing surveillance studies and there are limited literatures comparing the neurological disorders associated with newer-generation H1-antihistamines from real-world datasets.<h4>Aims</h4>We performed a comparative analysis of nervous system disorders and several newer-generation H1-antihistamines including: cetirizine, loratadine, levocetirizine, desloratadine and fexofenadine.<h4>Methods</h4>Disproportionality analysis was used to identify the suspected drug neurological adverse events associated with H1-antihistamines of interest via the Food and Drug Administration Adverse Event Reporting Sys","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-03T23:13:18.463Z","creation":"2025-04-03T23:13:18.463Z"},"accession":"S-EPMC11656970","cross_references":{"pubmed":["39696617"],"doi":["10.1186/s40360-024-00822-x"]}}