biostudies-literatureHu Wthe National Natural Science Foundation of China95https://www.ebi.ac.uk/biostudies/studies/S-EPMC11656970biostudies-literatureUnknown25(1)<h4>Background</h4>H1-antihistamines are widely used to treat symptoms depending on histamine release in a variety of conditions. However, neurological adverse events have been reported in post-marketing surveillance studies and there are limited literatures comparing the neurological disorders associated with newer-generation H1-antihistamines from real-world datasets.<h4>Aims</h4>We performed a comparative analysis of nervous system disorders and several newer-generation H1-antihistamines including: cetirizine, loratadine, levocetirizine, desloratadine and fexofenadine.<h4>Methods</h4>Disproportionality analysis was used to identify the suspected drug neurological adverse events associated with H1-antihistamines of interest via the Food and Drug Administration Adverse Event Reporting SysBMC pharmacology & toxicologyData mining in FAERS: association of newer-generation H1-antihistamines with nervous system disorders.PMC11656970No. 82071686Li HHu WZeng LChen LGan JZhang LFeng CfalseData mining in FAERS: association of newer-generation H1-antihistamines with nervous system disorders.<h4>Background</h4>H1-antihistamines are widely used to treat symptoms depending on histamine release in a variety of conditions. However, neurological adverse events have been reported in post-marketing surveillance studies and there are limited literatures comparing the neurological disorders associated with newer-generation H1-antihistamines from real-world datasets.<h4>Aims</h4>We performed a comparative analysis of nervous system disorders and several newer-generation H1-antihistamines including: cetirizine, loratadine, levocetirizine, desloratadine and fexofenadine.<h4>Methods</h4>Disproportionality analysis was used to identify the suspected drug neurological adverse events associated with H1-antihistamines of interest via the Food and Drug Administration Adverse Event Reporting Sys2024-01-01T00:00:00Z2024 Dec2025-04-03T23:13:18.463Z2025-04-03T23:13:18.463ZS-EPMC116569703969661710.1186/s40360-024-00822-x