{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zubeldia-Varela E"],"funding":["Japan Society for the Promotion of Science (JSPS)","Deutscher Akademischer Austausch Dienst (DAAD)","FEDER 'Investing in your future' for the thematic network and co-operative research centres RICORS 'Red de Enfermedades Inflamatorias (REI)'","Instituto de Salud Carlos III","European Regional Development Fund"],"pagination":["3430-3447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11657046"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(12)"],"pubmed_abstract":["<h4>Background</h4>The pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma and anaphylaxis Importantly, high-IgE levels are a poor prognostic factor in gastrointestinal allergies.<h4>Methods</h4>This study investigated how high-IgE levels influence the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock-in (IgEki) mice expressing high levels of IgE. In addition, correlation of the altered metabolome with gut microbiome was analysed.<h4>Results</h4>Ovalbumin-sensitized and egg-white diet-fed (OVA/EW) BALB/c WT mice developed moderate AE, whereas OVA/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulatio"],"journal":["Allergy"],"pubmed_title":["The impact of high-IgE levels on metabolome and microbiome in experimental allergic enteritis."],"pmcid":["PMC11657046"],"funding_grant_id":["PI19/00044","(RD21/0002/0008)","PI20/01366","PID2021‐122490NB‐I00","PI17/01087","PID2021-122490NB-I00"],"pubmed_authors":["Vieths S","Barbas C","Perez-Gordo M","Gonzalez-Menendez I","Martella M","Nochi T","Laino J","Yu P","Barber D","Toda M","Steigerwald H","Quintanilla-Martinez L","Krause M","Zubeldia-Varela E","Islam J","Blanco-Perez F","Barker-Tejeda TC","Rojo D","Villasenor A"],"additional_accession":[]},"is_claimable":false,"name":"The impact of high-IgE levels on metabolome and microbiome in experimental allergic enteritis.","description":"<h4>Background</h4>The pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma and anaphylaxis Importantly, high-IgE levels are a poor prognostic factor in gastrointestinal allergies.<h4>Methods</h4>This study investigated how high-IgE levels influence the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock-in (IgEki) mice expressing high levels of IgE. In addition, correlation of the altered metabolome with gut microbiome was analysed.<h4>Results</h4>Ovalbumin-sensitized and egg-white diet-fed (OVA/EW) BALB/c WT mice developed moderate AE, whereas OVA/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulatio","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-18T14:40:12.11Z","creation":"2025-04-07T00:56:43.927Z"},"accession":"S-EPMC11657046","cross_references":{"pubmed":["38932655"],"doi":["10.1111/all.16202"]}}