biostudies-literatureMou KNational Natural Science Foundation of ChinaLuzhou Science and Technology ProjectHejiang County People's Hospital - Southwest Medical University Science and Technology Cooperation ProjectLuzhou Science and Technology ProgramSichuan Science and Technology ProgramNatural Science Foundation of Sichuan Province1525https://www.ebi.ac.uk/biostudies/studies/S-EPMC11657210biostudies-literatureUnknown24(1)Caveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable for caveolar formation and function. An increasing number of studies have found that cavins are involved in tumor growth, invasion, metastasis, and angiogenesis and may have dual roles in the regulation of cancer. However, the expression and prognostic value of cavins in non-small cell lung cancer (NSCLC) remain unexplored. In this study, the expression, survival data, immune infiltration, and functional enrichment of cavins in patients with NSCLC were investigated using multiple databases. Furthermore, different subtypes of cavin-binding BMC cancerComprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer.PMC116572102023NSFSC18462021-jyj-812022YFS0636-C42022YFS0636-B42022HJXNYD112022HJXNYD162022-JYJ-12081903000Li GWang HWang JXiang LMou KHuang SLuo JZhang YLei YLuo YPeng LZhu SZhao HfalseComprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer.Caveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable for caveolar formation and function. An increasing number of studies have found that cavins are involved in tumor growth, invasion, metastasis, and angiogenesis and may have dual roles in the regulation of cancer. However, the expression and prognostic value of cavins in non-small cell lung cancer (NSCLC) remain unexplored. In this study, the expression, survival data, immune infiltration, and functional enrichment of cavins in patients with NSCLC were investigated using multiple databases. Furthermore, different subtypes of cavin-binding 2024-01-01T00:00:00Z2024 Dec2025-04-03T23:07:05.785Z2025-04-03T23:07:05.785ZS-EPMC116572103969545810.1186/s12885-024-13280-9