biostudies-literatureAlvarado MEuropean Social Fund PlusAgencia Estatal de InvestigaciónUCLMEuropean Regional Development Fundfoae039https://www.ebi.ac.uk/biostudies/studies/S-EPMC11657238biostudies-literatureUnknown24The drug-resistant pathogenic yeast Candidozyma auris (formerly named Candida auris) is considered a critical health problem of global importance. As the cell wall plays a crucial role in pathobiology, here we performed a detailed bioinformatic analysis of its biosynthesis in C. auris and related Candidozyma haemuli complex species using Candida albicans and Saccharomyces cerevisiae as references. Our data indicate that the cell wall architecture described for these reference yeasts is largely conserved in Candidozyma spp.; however, expansions or reductions in gene families point to subtle alterations, particularly with respect to β--1,3--glucan synthesis and remodeling, phosphomannosylation, β-mannosylation, and glycosylphosphatidylinositol (GPI) proteins. In several aspects, C. auris holFEMS yeast researchThe good, the bad, and the hazardous: comparative genomic analysis unveils cell wall features in the pathogen Candidozyma auris typical for both baker's yeast and Candida.PMC11657238CNS2022-135375PID2020-117983RB-I00SBPLY/23/180225/000029JDC2023-051226-IValentin Ede Groot PWJGomez-Molero EEraso EAlvarado MMateo EBlazquez-Munoz MTMunro CAGomez-Navajas JAFernandez-Sanchez SfalseThe good, the bad, and the hazardous: comparative genomic analysis unveils cell wall features in the pathogen Candidozyma auris typical for both baker's yeast and Candida.The drug-resistant pathogenic yeast Candidozyma auris (formerly named Candida auris) is considered a critical health problem of global importance. As the cell wall plays a crucial role in pathobiology, here we performed a detailed bioinformatic analysis of its biosynthesis in C. auris and related Candidozyma haemuli complex species using Candida albicans and Saccharomyces cerevisiae as references. Our data indicate that the cell wall architecture described for these reference yeasts is largely conserved in Candidozyma spp.; however, expansions or reductions in gene families point to subtle alterations, particularly with respect to β--1,3--glucan synthesis and remodeling, phosphomannosylation, β-mannosylation, and glycosylphosphatidylinositol (GPI) proteins. In several aspects, C. auris hol2024-01-01T00:00:00Z2024 Jan2026-07-03T03:24:59.906Z2025-04-04T21:45:00.34ZS-EPMC116572383965685710.1093/femsyr/foae039