{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Wienecke LM"],"pubmed_abstract":["<h4>Background</h4>Adults with congenital heart disease (ACHD) display changes in adaptive immunity related to early open-heart surgery and subsequent incidental thymectomy. In acquired heart failure (HF) systemic inflammation, innate and adaptive immune cells play an important role. However, cellular immune alterations of monocyte, T lymphocyte and natural killer (NK) cell subsets have not been related to HF in ACHD.<h4>Methods and results</h4>This cross-sectional study included 209 ACHD outpatients (mean age: 35.3 ± 11.0 years; NYHA class I/II/III-IV 64.1%/21.5%/14.4%; 59.8% male) and 21 healthy controls (29.8 ± 12.6 years; 47.6% male). Patients with clinical signs of infection, inflammatory diseases or malignancies were excluded. Flow cytometry of fresh whole blood revealed significantl"],"journal":["International journal of cardiology. Congenital heart disease"],"pagination":["100418"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11657347"],"repository":["biostudies-literature"],"pubmed_title":["Altered compositions of monocyte, T lymphocyte and NK cell subsets in heart failure of adult congenital heart disease."],"pmcid":["PMC11657347"],"pubmed_authors":["Westhoff-Bleck M","Fraccarollo D","Kockelmann F","Bauersachs J","Wienecke LM","Lemke LH","Galuppo P","Thol J"],"additional_accession":[]},"is_claimable":false,"name":"Altered compositions of monocyte, T lymphocyte and NK cell subsets in heart failure of adult congenital heart disease.","description":"<h4>Background</h4>Adults with congenital heart disease (ACHD) display changes in adaptive immunity related to early open-heart surgery and subsequent incidental thymectomy. In acquired heart failure (HF) systemic inflammation, innate and adaptive immune cells play an important role. However, cellular immune alterations of monocyte, T lymphocyte and natural killer (NK) cell subsets have not been related to HF in ACHD.<h4>Methods and results</h4>This cross-sectional study included 209 ACHD outpatients (mean age: 35.3 ± 11.0 years; NYHA class I/II/III-IV 64.1%/21.5%/14.4%; 59.8% male) and 21 healthy controls (29.8 ± 12.6 years; 47.6% male). Patients with clinical signs of infection, inflammatory diseases or malignancies were excluded. Flow cytometry of fresh whole blood revealed significantl","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T01:09:00.575Z","creation":"2025-04-04T01:09:00.575Z"},"accession":"S-EPMC11657347","cross_references":{"pubmed":["39713590"],"doi":["10.1016/j.ijcchd.2022.100418"]}}